TRAF2

From Wikipedia, the free encyclopedia

TNF receptor-associated factor 2
PDB rendering based on 1ca4.
Available structures: 1ca4, 1ca9, 1czy, 1czz, 1d00, 1d01, 1d0a, 1d0j, 1f3v, 1qsc
Identifiers
Symbol(s)	TRAF2; TRAP; MGC:45012; TRAP3
External IDs	OMIM: 601895 MGI: 101835 HomoloGene: 22520
Gene ontology Molecular Function: • signal transducer activity • receptor activity • protein binding • zinc ion binding • metal ion binding Biological Process: • positive regulation of T cell cytokine production • protein complex assembly • signal transduction • activation of NF-kappaB-inducing kinase • regulation of apoptosis • positive regulation of T cell activation
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	7186	22030
Ensembl	ENSG00000127191	ENSMUSG00000026942
Uniprot	Q12933	Q3TWR1
Refseq	NM_021138 (mRNA) NP_066961 (protein)	NM_009422 (mRNA) NP_033448 (protein)
Location	Chr 9: 138.9 - 138.94 Mb	Chr 2: 25.34 - 25.37 Mb
Pubmed search	[1]	[2]

TNF receptor-associated factor 2, also known as TRAF2, is a human gene.

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.^[1]

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