TRADD

From Wikipedia, the free encyclopedia

TNFRSF1A-associated via death domain

PDB rendering based on 1f2h.

Available structures: 1f2h, 1f3v

Identifiers

Symbol(s)

TRADD; Hs.89862; MGC11078

External IDs

OMIM: 603500 MGI: 109200 HomoloGene: 2807

Gene ontology
Molecular Function:	• signal transducer activity • identical protein binding
Biological Process:	• apoptosis • induction of apoptosis • signal transduction • positive regulation of I-kappaB kinase/NF-kappaB cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_153425 (mRNA)
NP_700474 (protein)

NM_001033161 (mRNA)
NP_001028333 (protein)

Location

Chr 16: 65.75 - 65.75 Mb

Chr 8: 108.15 - 108.15 Mb

Pubmed search

[1]

[2]

TNFRSF1A-associated via death domain, also known as TRADD, is a human gene.^[1]

TRADD is an adaptor protein.

The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway.^[1]

Signaling pathway of TNF-R1. Dashed grey lines represent multiple steps

[edit] References

^ ^a ^b Entrez Gene: TRADD TNFRSF1A-associated via death domain.

[edit] Further reading

Baker SJ, Reddy EP (1999). "Modulation of life and death by the TNF receptor superfamily.". Oncogene 17 (25): 3261–70. doi:10.1038/sj.onc.1202568. PMID 9916988.
Hsu H, Xiong J, Goeddel DV (1995). "The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation.". Cell 81 (4): 495–504. PMID 7758105.
Hsu H, Shu HB, Pan MG, Goeddel DV (1996). "TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways.". Cell 84 (2): 299–308. PMID 8565075.
Hsu H, Huang J, Shu HB, et al. (1996). "TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex.". Immunity 4 (4): 387–96. PMID 8612133.
Boldin MP, Goncharov TM, Goltsev YV, Wallach D (1996). "Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death.". Cell 85 (6): 803–15. PMID 8681376.
Takeuchi M, Rothe M, Goeddel DV (1996). "Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins.". J. Biol. Chem. 271 (33): 19935–42. PMID 8702708.
Kitson J, Raven T, Jiang YP, et al. (1996). "A death-domain-containing receptor that mediates apoptosis.". Nature 384 (6607): 372–5. doi:10.1038/384372a0. PMID 8934525.
Shu HB, Takeuchi M, Goeddel DV (1997). "The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex.". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 13973–8. PMID 8943045.
Izumi KM, Kieff ED (1997). "The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-kappaB.". Proc. Natl. Acad. Sci. U.S.A. 94 (23): 12592–7. PMID 9356494.
Wajant H, Johannes FJ, Haas E, et al. (1998). "Dominant-negative FADD inhibits TNFR60-, Fas/Apo1- and TRAIL-R/Apo2-mediated cell death but not gene induction.". Curr. Biol. 8 (2): 113–6. PMID 9427646.
Chaudhary PM, Eby M, Jasmin A, et al. (1998). "Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway.". Immunity 7 (6): 821–30. PMID 9430227.
Pan G, Bauer JH, Haridas V, et al. (1998). "Identification and functional characterization of DR6, a novel death domain-containing TNF receptor.". FEBS Lett. 431 (3): 351–6. PMID 9714541.
Jones SJ, Ledgerwood EC, Prins JB, et al. (1999). "TNF recruits TRADD to the plasma membrane but not the trans-Golgi network, the principal subcellular location of TNF-R1.". J. Immunol. 162 (2): 1042–8. PMID 9916731.
Schütze S, Machleidt T, Adam D, et al. (1999). "Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling.". J. Biol. Chem. 274 (15): 10203–12. PMID 10187805.
Sanz L, Sanchez P, Lallena MJ, et al. (1999). "The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation.". EMBO J. 18 (11): 3044–53. doi:10.1093/emboj/18.11.3044. PMID 10356400.
Costanzo A, Guiet C, Vito P (1999). "c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB.". J. Biol. Chem. 274 (29): 20127–32. PMID 10400625.
Wang Y, Wu TR, Cai S, et al. (2000). "Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation.". Mol. Cell. Biol. 20 (13): 4505–12. PMID 10848577.
Park YC, Ye H, Hsia C, et al. (2000). "A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction.". Cell 101 (7): 777–87. PMID 10892748.
Tsao DH, McDonagh T, Telliez JB, et al. (2000). "Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway.". Mol. Cell 5 (6): 1051–7. PMID 10911999.