TPX2

From Wikipedia, the free encyclopedia

TPX2, microtubule-associated, homolog (Xenopus laevis)

PDB rendering based on 1ol5.

Available structures: 1ol5

Identifiers

Symbol(s)

TPX2; p100; C20orf1; C20orf2; DIL-2; DIL2; FLS353; GD:C20orf1; HCA519; HCTP4; REPP86

External IDs

OMIM: 605917 MGI: 1919369 HomoloGene: 8107

Gene ontology
Molecular Function:	• protein binding • ATP binding • GTP binding
Cellular Component:	• spindle pole • nucleus
Biological Process:	• mitosis • cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_012112 (mRNA)
NP_036244 (protein)

XM_974244 (mRNA)
XP_979338 (protein)

Location

Chr 20: 29.79 - 29.85 Mb

Chr 2: 152.54 - 152.59 Mb

Pubmed search

[1]

[2]

TPX2, microtubule-associated, homolog (Xenopus laevis), also known as TPX2, is a human gene.^[1]

[edit] References

^ Entrez Gene: TPX2 TPX2, microtubule-associated, homolog (Xenopus laevis).

[edit] Further reading

Heidebrecht HJ, Buck F, Steinmann J, et al. (1997). "p100: a novel proliferation-associated nuclear protein specifically restricted to cell cycle phases S, G2, and M.". Blood 90 (1): 226-33. PMID 9207457.
Zhang Y, Heidebrecht H, Rott A, et al. (1999). "Assignment of human proliferation associated p100 gene (C20orf1) to human chromosome band 20q11.2 by in situ hybridization.". Cytogenet. Cell Genet. 84 (3-4): 182-3. PMID 10393424.
Manda R, Kohno T, Matsuno Y, et al. (1999). "Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display.". Genomics 61 (1): 5-14. doi:10.1006/geno.1999.5939. PMID 10512675.
Wittmann T, Wilm M, Karsenti E, Vernos I (2000). "TPX2, A novel xenopus MAP involved in spindle pole organization.". J. Cell Biol. 149 (7): 1405-18. PMID 10871281.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052.
Wang Y, Han KJ, Pang XW, et al. (2002). "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies.". J. Immunol. 169 (2): 1102-9. PMID 12097419.
Kufer TA, Silljé HH, Körner R, et al. (2002). "Human TPX2 is required for targeting Aurora-A kinase to the spindle.". J. Cell Biol. 158 (4): 617-23. doi:10.1083/jcb.200204155. PMID 12177045.
Gruss OJ, Wittmann M, Yokoyama H, et al. (2004). "Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells.". Nat. Cell Biol. 4 (11): 871-9. doi:10.1038/ncb870. PMID 12389033.
Garrett S, Auer K, Compton DA, Kapoor TM (2003). "hTPX2 is required for normal spindle morphology and centrosome integrity during vertebrate cell division.". Curr. Biol. 12 (23): 2055-9. PMID 12477396.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Heidebrecht HJ, Adam-Klages S, Szczepanowski M, et al. (2004). "repp86: A human protein associated in the progression of mitosis.". Mol. Cancer Res. 1 (4): 271-9. PMID 12612055.
Bayliss R, Sardon T, Vernos I, Conti E (2003). "Structural basis of Aurora-A activation by TPX2 at the mitotic spindle.". Mol. Cell 12 (4): 851-62. PMID 14580337.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Cassimeris L, Morabito J (2004). "TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly.". Mol. Biol. Cell 15 (4): 1580-90. doi:10.1091/mbc.E03-07-0544. PMID 14718566.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Maxwell CA, Keats JJ, Belch AR, et al. (2005). "Receptor for hyaluronan-mediated motility correlates with centrosome abnormalities in multiple myeloma and maintains mitotic integrity.". Cancer Res. 65 (3): 850-60. PMID 15705883.
Stewart S, Fang G (2005). "Anaphase-promoting complex/cyclosome controls the stability of TPX2 during mitotic exit.". Mol. Cell. Biol. 25 (23): 10516-27. doi:10.1128/MCB.25.23.10516-10527.2005. PMID 16287863.
Ma Y, Lin D, Sun W, et al. (2006). "Expression of targeting protein for xklp2 associated with both malignant transformation of respiratory epithelium and progression of squamous cell lung cancer.". Clin. Cancer Res. 12 (4): 1121-7. doi:10.1158/1078-0432.CCR-05-1766. PMID 16489064.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391-6. doi:10.1073/pnas.0507066103. PMID 16565220.