TP53RK

From Wikipedia, the free encyclopedia

TP53 regulating kinase

Identifiers

TP53RK; BUD32; C20orf64; Nori-2; Nori-2p; PRPK; dJ101A2

External IDs

OMIM: 608679 MGI: 1914050 HomoloGene: 6042

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • protein-tyrosine kinase activity • protein binding • ATP binding • transferase activity
Cellular Component:	• nucleus
Biological Process:	• protein amino acid phosphorylation

Orthologs

Human

Mouse

Refseq

NM_033550 (mRNA)
NP_291028 (protein)

NM_023815 (mRNA)
NP_076304 (protein)

Location

Chr 20: 44.75 - 44.75 Mb

Chr 2: 166.48 - 166.49 Mb

Pubmed search

[1]

[2]

TP53 regulating kinase, also known as TP53RK, is a human gene.^[1]

[edit] References

^ Entrez Gene: TP53RK TP53 regulating kinase.

[edit] Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Abe Y, Matsumoto S, Wei S, et al. (2001). "Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes.". J. Biol. Chem. 276 (47): 44003-11. doi:10.1074/jbc.M105669200. PMID 11546806.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Miyoshi A, Kito K, Aramoto T, et al. (2003). "Identification of CGI-121, a novel PRPK (p53-related protein kinase)-binding protein.". Biochem. Biophys. Res. Commun. 303 (2): 399-405. PMID 12659830.
Facchin S, Lopreiato R, Ruzzene M, et al. (2004). "Functional homology between yeast piD261/Bud32 and human PRPK: both phosphorylate p53 and PRPK partially complements piD261/Bud32 deficiency.". FEBS Lett. 549 (1-3): 63-6. PMID 12914926.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Wang SC, Lien HC, Xia W, et al. (2004). "Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2.". Cancer Cell 6 (3): 251-61. doi:10.1016/j.ccr.2004.07.012. PMID 15380516.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Abe Y, Takeuchi T, Imai Y, et al. (2006). "A Small Ras-like protein Ray/Rab1c modulates the p53-regulating activity of PRPK.". Biochem. Biophys. Res. Commun. 344 (1): 377-85. doi:10.1016/j.bbrc.2006.03.071. PMID 16600182.