TP53I3

From Wikipedia, the free encyclopedia

Tumor protein p53 inducible protein 3

PDB rendering based on 2j8z.

Available structures: 2j8z, 2oby

Identifiers

Symbol(s)

TP53I3; PIG3

External IDs

OMIM: 605171 HomoloGene: 36617

Gene ontology
Molecular Function:	• molecular_function • zinc ion binding • oxidoreductase activity
Cellular Component:	• cellular_component
Biological Process:	• induction of apoptosis by oxidative stress

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_004881 (mRNA)
NP_004872 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 2: 24.15 - 24.16 Mb

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Pubmed search

[1]

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Tumor protein p53 inducible protein 3, also known as TP53I3, is a human gene.^[1]

The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. At least two transcript variants encoding the same protein have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: TP53I3 tumor protein p53 inducible protein 3.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Polyak K, Xia Y, Zweier JL, et al. (1997). "A model for p53-induced apoptosis.". Nature 389 (6648): 300-5. doi:10.1038/38525. PMID 9305847.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Flatt PM, Polyak K, Tang LJ, et al. (2000). "p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest.". Cancer Lett. 156 (1): 63-72. PMID 10840161.
Contente A, Dittmer A, Koch MC, et al. (2002). "A polymorphic microsatellite that mediates induction of PIG3 by p53.". Nat. Genet. 30 (3): 315-20. doi:10.1038/ng836. PMID 11919562.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Nicholls CD, Shields MA, Lee PW, et al. (2004). "UV-dependent alternative splicing uncouples p53 activity and PIG3 gene function through rapid proteolytic degradation.". J. Biol. Chem. 279 (23): 24171-8. doi:10.1074/jbc.M401049200. PMID 15067011.
Pospísilová S, Siligan C, Ban J, et al. (2004). "Constitutive and DNA damage inducible activation of pig3 and MDM2 genes by tumor-derived p53 mutant C277Y.". Mol. Cancer Res. 2 (5): 296-304. PMID 15192123.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724-31. doi:10.1038/nature03466. PMID 15815621.
Rohaly G, Chemnitz J, Dehde S, et al. (2005). "A novel human p53 isoform is an essential element of the ATR-intra-S phase checkpoint.". Cell 122 (1): 21-32. doi:10.1016/j.cell.2005.04.032. PMID 16009130.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.