Toxic multinodular goitre

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Toxic multinodular goitre Classification and external resources
ICD-10	E05.2
ICD-9	242.3
DiseasesDB	13184
MedlinePlus	000317
eMedicine	med/920

Toxic multinodular goitre (also known as toxic nodular goitre, toxic nodular struma) is a form of hyperthyroidism - where there is excess production of thyroid hormones.

It is the second most common cause of hyperthyroidism after Graves disease.

Contents 1 Symptoms 2 Related eponym 3 Footnotes 4 External links

[edit] Symptoms

Symptoms of toxic multinodular goitre are similar to that of hyperthyroidism, including:

• heat intolerance
• hyperkinesis
• tremor
• irritability
• weight loss
• increased appetite
• goitre (swelling of the thyroid gland)
• tachycardia (high heart rate - above 180 bpm at rest)

[edit] Related eponym

Plummer's disease is named after an American physician Henry Stanley Plummer but refers to a single toxic nodule (adenoma) which may present with the background of a suppressed multinodular goitre.^[1]

[edit] Footnotes

1. ^ Plummer's disease eponymously named after Henry Stanley Plummer at Who Named It

[edit] External links

• Photo of patient
• Photo of goitre

v • d • e Endocrine pathology: endocrine diseases (E00-35, 240-259) Thyroid Hypothyroidism (Iodine deficiency, Cretinism, Congenital hypothyroidism, Goitre, Myxedema) - Hyperthyroidism (Graves disease, Toxic multinodular goitre, Teratoma with thyroid tissue or Struma ovarii) - Thyroiditis (De Quervain's thyroiditis, Hashimoto's thyroiditis, Riedel's thyroiditis) - Euthyroid sick syndrome Pancreas Diabetes mellitus (type 1, type 2, coma, angiopathy, ketoacidosis, nephropathy, neuropathy, retinopathy, MODY) - Hypoglycemia - Hyperinsulinism - Zollinger-Ellison syndrome - insulin receptor (Rabson-Mendenhall syndrome) Parathyroid Hypoparathyroidism (Pseudohypoparathyroidism) - Hyperparathyroidism (Primary, Secondary, Tertiary) Pituitary Hyperpituitarism (Acromegaly, Hyperprolactinaemia, SIADH) - Hypopituitarism (Simmonds' disease/Sheehan's syndrome, Kallmann syndrome, Growth hormone deficiency, Diabetes insipidus) - Adiposogenital dystrophy - Empty sella syndrome - Pituitary apoplexy - Adrenocorticotropic hormone deficiency Adrenal Cushing's syndrome (Nelson's syndrome, Pseudo-Cushing's syndrome) - CAH (Lipoid, 3β, 11β, 17α, 21α) - Hyperaldosteronism (Conn syndrome, Bartter syndrome) - Adrenal insufficiency (Addison's disease) - Hypoaldosteronism Gonads ovarian dysfunction (Polycystic ovary syndrome, Premature ovarian failure) - testicular dysfunction (5-alpha-reductase deficiency) - testosterone biosynthesis (17-beta-hydroxysteroid dehydrogenase deficiency) - general (Hypogonadism, Delayed puberty, Precocious puberty) Other Androgen insensitivity syndrome - Autoimmune polyendocrine syndrome - Carcinoid syndrome - Gigantism - Short stature (Laron syndrome, Psychogenic dwarfism) - Multiple endocrine neoplasia (1, 2) - Progeria - Woodhouse-Sakati syndrome