TOX

From Wikipedia, the free encyclopedia

Thymus high mobility group box protein TOX

PDB rendering based on 2co9.

Available structures: 2co9

Identifiers

Symbol(s)

TOX; KIAA0808

External IDs

OMIM: 606863 MGI: 2181659 HomoloGene: 8822

Gene ontology
Molecular Function:	• DNA binding
Cellular Component:	• chromatin • nucleus
Biological Process:	• regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014729 (mRNA)
NP_055544 (protein)

XM_974192 (mRNA)
XP_979286 (protein)

Location

Chr 8: 59.88 - 60.19 Mb

Chr 4: 6.61 - 6.92 Mb

Pubmed search

[1]

[2]

Thymus high mobility group box protein TOX, also known as TOX, is a human gene.^[1]

Some high-mobility group (HMG) box proteins (e.g., LEF1; MIM 153245) contain a single HMG box motif and bind DNA in a sequence-specific manner, while other members of this family (e.g., HMG1; MIM 163905) have multiple HMG boxes and bind DNA in a sequence-independent but structure-dependent manner. All HMG box proteins are able to induce a sharp bend in DNA. TOX contains a single HMG box motif.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: TOX thymus high mobility group box protein TOX.

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99-106. PMID 12168954.
Sebastiani P, Wang L, Nolan VG, et al.. "Fetal hemoglobin in sickle cell anemia: Bayesian modeling of genetic associations.". Am. J. Hematol. 83 (3): 189-95. doi:10.1002/ajh.21048. PMID 17918249.
Stacey SN, Manolescu A, Sulem P, et al. (2007). "Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer.". Nat. Genet. 39 (7): 865-9. doi:10.1038/ng2064. PMID 17529974.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Aliahmad P, O'Flaherty E, Han P, et al. (2004). "TOX provides a link between calcineurin activation and CD8 lineage commitment.". J. Exp. Med. 199 (8): 1089-99. doi:10.1084/jem.20040051. PMID 15078895.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
O'Flaherty E, Kaye J (2003). "TOX defines a conserved subfamily of HMG-box proteins.". BMC Genomics 4 (1): 13. PMID 12697058.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Wilkinson B, Chen JY, Han P, et al. (2002). "TOX: an HMG box protein implicated in the regulation of thymocyte selection.". Nat. Immunol. 3 (3): 272-80. doi:10.1038/ni767. PMID 11850626.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277-86. PMID 9872452.