Topological derivative
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In the field of shape optimization, a topological derivative is, conceptually, a derivative of a function of a region with respect to small changes in its topology, such as adding a small hole.
Shape optimization concerns itself with finding an optimal shape. That is, find Ω to minimize some scalar-valued objective function, J(Ω). Neglecting changes in topology, an initial guess can be improved by perturbing the shape of Ω by methods of calculus of variations and functional analysis. However, this does not permit a discrete operation such as making a hole in Ω.