Top7
From Wikipedia, the free encyclopedia
Top7 is an artificial 93-amino acid protein, classified as a de novo protein since it was designed by Brian Kuhlman in David Baker's laboratory at the University of Washington and the Fred Hutchinson Cancer Research Center to have a unique fold not found in nature. The protein was designed ab initio on a computer with the help of protein structure prediction algorithms. X-ray crystallography on the protein after it was made, revealed that the structure was indeed very similar to the computer predicted structure. The structure consists of two alpha helices and two beta sheets.
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