TOPORS

From Wikipedia, the free encyclopedia

Topoisomerase I binding, arginine/serine-rich

Identifiers

TOPORS; LUN; TP53BPL

External IDs

OMIM: 609507 MGI: 2146189 HomoloGene: 4237

Gene ontology
Molecular Function:	• DNA binding • antigen binding • protein binding • zinc ion binding • ligase activity • DNA topoisomerase I binding • metal ion binding
Cellular Component:	• nucleus • nuclear speck
Biological Process:	• transcription • ubiquitin cycle • apoptosis • response to DNA damage stimulus • regulation of cell proliferation • positive regulation of transcription • maintenance of protein localization in nucleus

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005802 (mRNA)
NP_005793 (protein)

NM_134097 (mRNA)
NP_598858 (protein)

Location

Chr 9: 32.53 - 32.54 Mb

Chr 4: 40.45 - 40.46 Mb

Pubmed search

[1]

[2]

Topoisomerase I binding, arginine/serine-rich, also known as TOPORS, is a human gene.^[1]

[edit] References

^ Entrez Gene: TOPORS topoisomerase I binding, arginine/serine-rich.

[edit] Further reading

Haluska P, Saleem A, Rasheed Z, et al. (1999). "Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein.". Nucleic Acids Res. 27 (12): 2538–44. PMID 10352183.
Zhou R, Wen H, Ao SZ (1999). "Identification of a novel gene encoding a p53-associated protein.". Gene 235 (1-2): 93–101. PMID 10415337.
Souto-Carneiro MM, Krenn V, Hermann R, et al. (2001). "IgVH genes from different anatomical regions, with different histopathological patterns, of a rheumatoid arthritis patient suggest cyclic re-entry of mature synovial B-cells in the hypermutation process.". Arthritis Res. 2 (4): 303–14. PMID 11056671.
Chu D, Kakazu N, Gorrin-Rivas MJ, et al. (2001). "Cloning and characterization of LUN, a novel ring finger protein that is highly expressed in lung and specifically binds to a palindromic sequence.". J. Biol. Chem. 276 (17): 14004–13. doi:10.1074/jbc.M010262200. PMID 11278651.
Weger S, Hammer E, Heilbronn R (2002). "Topors, a p53 and topoisomerase I binding protein, interacts with the adeno-associated virus (AAV-2) Rep78/68 proteins and enhances AAV-2 gene expression.". J. Gen. Virol. 83 (Pt 3): 511–6. PMID 11842245.
Rasheed ZA, Saleem A, Ravee Y, et al. (2002). "The topoisomerase I-binding RING protein, topors, is associated with promyelocytic leukemia nuclear bodies.". Exp. Cell Res. 277 (2): 152–60. PMID 12083797.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis.". Exp. Cell Res. 288 (1): 35–50. PMID 12878157.
Weger S, Hammer E, Engstler M (2003). "The DNA topoisomerase I binding protein topors as a novel cellular target for SUMO-1 modification: characterization of domains necessary for subcellular localization and sumolation.". Exp. Cell Res. 290 (1): 13–27. PMID 14516784.
Saleem A, Dutta J, Malegaonkar D, et al. (2004). "The topoisomerase I- and p53-binding protein topors is differentially expressed in normal and malignant human tissues and may function as a tumor suppressor.". Oncogene 23 (31): 5293–300. doi:10.1038/sj.onc.1207700. PMID 15107820.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Rajendra R, Malegaonkar D, Pungaliya P, et al. (2004). "Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53.". J. Biol. Chem. 279 (35): 36440–4. doi:10.1074/jbc.C400300200. PMID 15247280.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Oyanagi H, Takenaka K, Ishikawa S, et al. (2005). "Expression of LUN gene that encodes a novel RING finger protein is correlated with development and progression of non-small cell lung cancer.". Lung Cancer 46 (1): 21–8. doi:10.1016/j.lungcan.2004.03.009. PMID 15364129.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Flatten K, Dai NT, Vroman BT, et al. (2005). "The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons.". J. Biol. Chem. 280 (14): 14349–55. doi:10.1074/jbc.M411890200. PMID 15699047.
Lin L, Ozaki T, Takada Y, et al. (2005). "topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage.". Oncogene 24 (21): 3385–96. doi:10.1038/sj.onc.1208554. PMID 15735665.
Weger S, Hammer E, Heilbronn R (2005). "Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivo.". FEBS Lett. 579 (22): 5007–12. doi:10.1016/j.febslet.2005.07.088. PMID 16122737.
Papaioannou M, Chakarova CF, Prescott DC, et al. (2006). "A new locus (RP31) for autosomal dominant retinitis pigmentosa maps to chromosome 9p.". Hum. Genet. 118 (3-4): 501–3. doi:10.1007/s00439-005-0063-3. PMID 16189705.