TOPBP1

From Wikipedia, the free encyclopedia

Topoisomerase (DNA) II binding protein 1

PDB rendering based on 1wf6.

Available structures: 1wf6

Identifiers

Symbol(s)

TOPBP1; TOP2BP1

External IDs

OMIM: 607760 MGI: 1920018 HomoloGene: 38262

Gene ontology
Molecular Function:	• DNA binding • protein C-terminus binding
Cellular Component:	• condensed nuclear chromosome • intracellular • nucleus
Biological Process:	• DNA repair

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007027 (mRNA)
NP_008958 (protein)

NM_176979 (mRNA)
NP_795953 (protein)

Location

Chr 3: 134.8 - 134.86 Mb

Chr 9: 103.16 - 103.21 Mb

Pubmed search

[1]

[2]

Topoisomerase (DNA) II binding protein 1, also known as TOPBP1, is a human gene.^[1]

This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.^[1]

[edit] References

^ ^a ^b Entrez Gene: TOPBP1 topoisomerase (DNA) II binding protein 1.

[edit] Further reading

Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.". DNA Res. 3 (5): 321-9, 341-54. PMID 9039502.
Yamane K, Kawabata M, Tsuruo T (1997). "A DNA-topoisomerase-II-binding protein with eight repeating regions similar to DNA-repair enzymes and to a cell-cycle regulator.". Eur. J. Biochem. 250 (3): 794-9. PMID 9461304.
Yamane K, Tsuruo T (1999). "Conserved BRCT regions of TopBP1 and of the tumor suppressor BRCA1 bind strand breaks and termini of DNA.". Oncogene 18 (37): 5194-203. doi:10.1038/sj.onc.1202922. PMID 10498869.
Mäkiniemi M, Hillukkala T, Tuusa J, et al. (2001). "BRCT domain-containing protein TopBP1 functions in DNA replication and damage response.". J. Biol. Chem. 276 (32): 30399-406. doi:10.1074/jbc.M102245200. PMID 11395493.
Honda Y, Tojo M, Matsuzaki K, et al. (2002). "Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response.". J. Biol. Chem. 277 (5): 3599-605. doi:10.1074/jbc.M104347200. PMID 11714696.
Yamane K, Wu X, Chen J (2002). "A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.". Mol. Cell. Biol. 22 (2): 555-66. PMID 11756551.
Boner W, Taylor ER, Tsirimonaki E, et al. (2002). "A Functional interaction between the human papillomavirus 16 transcription/replication factor E2 and the DNA damage response protein TopBP1.". J. Biol. Chem. 277 (25): 22297-303. doi:10.1074/jbc.M202163200. PMID 11934899.
Herold S, Wanzel M, Beuger V, et al. (2002). "Negative regulation of the mammalian UV response by Myc through association with Miz-1.". Mol. Cell 10 (3): 509-21. PMID 12408820.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773-84. doi:10.1101/gr.406902. PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Liu K, Lin FT, Ruppert JM, Lin WC (2003). "Regulation of E2F1 by BRCT domain-containing protein TopBP1.". Mol. Cell. Biol. 23 (9): 3287-304. PMID 12697828.
Xu ZX, Timanova-Atanasova A, Zhao RX, Chang KS (2003). "PML colocalizes with and stabilizes the DNA damage response protein TopBP1.". Mol. Cell. Biol. 23 (12): 4247-56. PMID 12773567.
Yamane K, Chen J, Kinsella TJ (2003). "Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint.". Cancer Res. 63 (12): 3049-53. PMID 12810625.
Greer DA, Besley BD, Kennedy KB, Davey S (2003). "hRad9 rapidly binds DNA containing double-strand breaks and is required for damage-dependent topoisomerase II beta binding protein 1 focus formation.". Cancer Res. 63 (16): 4829-35. PMID 12941802.
Manke IA, Lowery DM, Nguyen A, Yaffe MB (2003). "BRCT repeats as phosphopeptide-binding modules involved in protein targeting.". Science 302 (5645): 636-9. doi:10.1126/science.1088877. PMID 14576432.
Yu X, Chini CC, He M, et al. (2003). "The BRCT domain is a phospho-protein binding domain.". Science 302 (5645): 639-42. doi:10.1126/science.1088753. PMID 14576433.
Liu K, Luo Y, Lin FT, Lin WC (2004). "TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival.". Genes Dev. 18 (6): 673-86. doi:10.1101/gad.1180204. PMID 15075294.
Reini K, Uitto L, Perera D, et al. (2005). "TopBP1 localises to centrosomes in mitosis and to chromosome cores in meiosis.". Chromosoma 112 (7): 323-30. doi:10.1007/s00412-004-0277-5. PMID 15138768.
Hassel S, Eichner A, Yakymovych M, et al. (2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry.". Proteomics 4 (5): 1346-58. doi:10.1002/pmic.200300770. PMID 15188402.
Yoshida K, Inoue I (2004). "Expression of MCM10 and TopBP1 is regulated by cell proliferation and UV irradiation via the E2F transcription factor.". Oncogene 23 (37): 6250-60. doi:10.1038/sj.onc.1207829. PMID 15195143.