TOP1

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Topoisomerase (DNA) I
PDB rendering based on 1a31.
Available structures: 1a31, 1a35, 1a36, 1ej9, 1k4s, 1k4t, 1lpq, 1nh3, 1r49, 1rr8, 1rrj, 1sc7, 1seu, 1t8i, 1tl8
Identifiers
Symbol(s)	TOP1; TOPI
External IDs	OMIM: 126420 MGI: 98788 HomoloGene: 2467
Gene ontology Molecular Function: • chromatin binding • DNA topoisomerase type I activity • DNA topoisomerase (ATP-hydrolyzing) activity • protein binding Cellular Component: • nucleus • nucleoplasm • chromosome • nucleolus • cytoplasm • perikaryon Biological Process: • DNA replication • DNA topological change • embryonic cleavage
Orthologs
	Human	Mouse
Entrez	7150	21969
Ensembl	ENSG00000198900	ENSMUSG00000070544
Uniprot	P11387	Q3TPX7
Refseq	NM_003286 (mRNA) NP_003277 (protein)	NM_009408 (mRNA) NP_033434 (protein)
Location	Chr 20: 39.09 - 39.19 Mb	Chr 2: 160.34 - 160.41 Mb
Pubmed search	[1]	[2]

Topoisomerase (DNA) I, also known as TOP1, is a human gene.

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22.^[1]

[edit] See also

• Type I topoisomerase
• Topoisomerase

[edit] References

[edit] Further reading