TOMM34

From Wikipedia, the free encyclopedia

Translocase of outer mitochondrial membrane 34

Identifiers

TOMM34; HTOM34P; TOM34; URCC3

External IDs

MGI: 1914395 HomoloGene: 4956

Gene ontology
Molecular Function:	• signal sequence binding • protein binding
Cellular Component:	• mitochondrion • mitochondrial outer membrane • membrane • integral to membrane
Biological Process:	• protein folding • protein targeting to mitochondrion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006809 (mRNA)
NP_006800 (protein)

NM_025996 (mRNA)
NP_080272 (protein)

Location

Chr 20: 43 - 43.02 Mb

Chr 2: 163.74 - 163.76 Mb

Pubmed search

[1]

[2]

Translocase of outer mitochondrial membrane 34, also known as TOMM34, is a human gene.^[1]

The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats.^[1]

[edit] References

^ ^a ^b Entrez Gene: TOMM34 translocase of outer mitochondrial membrane 34.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Nuttall SD, Hanson BJ, Mori M, Hoogenraad NJ (1997). "hTom34: a novel translocase for the import of proteins into human mitochondria.". DNA Cell Biol. 16 (9): 1067–74. PMID 9324309.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Young JC, Obermann WM, Hartl FU (1998). "Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90.". J. Biol. Chem. 273 (29): 18007–10. PMID 9660753.
Chewawiwat N, Yano M, Terada K, et al. (1999). "Characterization of the novel mitochondrial protein import component, Tom34, in mammalian cells.". J. Biochem. 125 (4): 721–7. PMID 10101285.
Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20.". Genomics 76 (1-3): 45–57. doi:10.1006/geno.2001.6584. PMID 11549316.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Mukhopadhyay A, Avramova LV, Weiner H (2002). "Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins.". Arch. Biochem. Biophys. 400 (1): 97–104. doi:10.1006/abbi.2002.2777. PMID 11913975.
Yang CS, Weiner H (2002). "Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol.". Arch. Biochem. Biophys. 400 (1): 105–10. doi:10.1006/abbi.2002.2778. PMID 11913976.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Shimokawa T, Matsushima S, Tsunoda T, et al. (2006). "Identification of TOMM34, which shows elevated expression in the majority of human colon cancers, as a novel drug target.". Int. J. Oncol. 29 (2): 381–6. PMID 16820880.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.