TOMM20

From Wikipedia, the free encyclopedia

Translocase of outer mitochondrial membrane 20 homolog (yeast)

PDB rendering based on 1om2.

Available structures: 1om2, 1wt4, 2cuv

Identifiers

Symbol(s)

TOMM20; KIAA0016; MAS20; MGC117367; MOM19; TOM20

External IDs

OMIM: 601848 MGI: 1915202 HomoloGene: 44649

Gene ontology
Molecular Function:	• protein transmembrane transporter activity
Cellular Component:	• mitochondrion • mitochondrial outer membrane translocase complex • membrane • integral to membrane • outer membrane
Biological Process:	• protein targeting • protein targeting to mitochondrion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014765 (mRNA)
NP_055580 (protein)

NM_024214 (mRNA)
NP_077176 (protein)

Location

Chr 1: 233.34 - 233.36 Mb

Chr 8: 129.82 - 129.83 Mb

Pubmed search

[1]

[2]

Translocase of outer mitochondrial membrane 20 homolog (yeast), also known as TOMM20, is a human gene.^[1]

[edit] References

^ Entrez Gene: TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast).

[edit] Further reading

Seki N, Moczko M, Nagase T, et al. (1996). "A human homolog of the mitochondrial protein import receptor Mom19 can assemble with the yeast mitochondrial receptor complex.". FEBS Lett. 375 (3): 307–10. PMID 7498524.
Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.". DNA Res. 1 (1): 27–35. PMID 7584026.
Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement).". DNA Res. 1 (1): 47–56. PMID 7584028.
Goping IS, Millar DG, Shore GC (1995). "Identification of the human mitochondrial protein import receptor, huMas20p. Complementation of delta mas20 in yeast.". FEBS Lett. 373 (1): 45–50. PMID 7589431.
Schleiff E, Shore GC, Goping IS (1997). "Human mitochondrial import receptor, Tom20p. Use of glutathione to reveal specific interactions between Tom20-glutathione S-transferase and mitochondrial precursor proteins.". FEBS Lett. 404 (2-3): 314–8. PMID 9119086.
Schleiff E, Shore GC, Goping IS (1997). "Interactions of the human mitochondrial protein import receptor, hTom20, with precursor proteins in vitro reveal pleiotropic specificities and different receptor domain requirements.". J. Biol. Chem. 272 (28): 17784–9. PMID 9211931.
Schleiff E, Turnbull JL (1998). "Characterization of the N-terminal targeting signal binding domain of the mitochondrial outer membrane receptor, Tom20.". Biochemistry 37 (38): 13052–8. doi:10.1021/bi980746y. PMID 9748310.
Yano M, Kanazawa M, Terada K, et al. (1998). "Functional analysis of human mitochondrial receptor Tom20 for protein import into mitochondria.". J. Biol. Chem. 273 (41): 26844–51. PMID 9756929.
Hernández JM, Giner P, Hernández-Yago J (1999). "Gene structure of the human mitochondrial outer membrane receptor Tom20 and evolutionary study of its family of processed pseudogenes.". Gene 239 (2): 283–91. PMID 10548729.
Suzuki H, Okazawa Y, Komiya T, et al. (2001). "Characterization of rat TOM40, a central component of the preprotein translocase of the mitochondrial outer membrane.". J. Biol. Chem. 275 (48): 37930–6. doi:10.1074/jbc.M006558200. PMID 10980201.
Yano M, Hoogenraad N, Terada K, Mori M (2000). "Identification and functional analysis of human Tom22 for protein import into mitochondria.". Mol. Cell. Biol. 20 (19): 7205–13. PMID 10982837.
Abdul KM, Terada K, Yano M, et al. (2000). "Functional analysis of human metaxin in mitochondrial protein import in cultured cells and its relationship with the Tom complex.". Biochem. Biophys. Res. Commun. 276 (3): 1028–34. doi:10.1006/bbrc.2000.3589. PMID 11027586.
Mukhopadhyay A, Avramova LV, Weiner H (2002). "Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins.". Arch. Biochem. Biophys. 400 (1): 97–104. doi:10.1006/abbi.2002.2777. PMID 11913975.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Yano M, Terada K, Mori M (2003). "AIP is a mitochondrial import mediator that binds to both import receptor Tom20 and preproteins.". J. Cell Biol. 163 (1): 45–56. doi:10.1083/jcb.200305051. PMID 14557246.
Yano M, Terada K, Mori M (2004). "Mitochondrial import receptors Tom20 and Tom22 have chaperone-like activity.". J. Biol. Chem. 279 (11): 10808–13. doi:10.1074/jbc.M311710200. PMID 14699115.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Humphries AD, Streimann IC, Stojanovski D, et al. (2005). "Dissection of the mitochondrial import and assembly pathway for human Tom40.". J. Biol. Chem. 280 (12): 11535–43. doi:10.1074/jbc.M413816200. PMID 15644312.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.