TOLLIP

From Wikipedia, the free encyclopedia

Toll interacting protein

PDB rendering based on 1wgl.

Available structures: 1wgl

Identifiers

Symbol(s)

TOLLIP; FLJ33531; IL-1RAcPIP

External IDs

OMIM: 606277 MGI: 1891808 HomoloGene: 10375

Gene ontology
Molecular Function:	• signal transducer activity • Toll binding • protein binding
Cellular Component:	• cytoplasm • interleukin-18 receptor complex • interleukin-1 receptor complex
Biological Process:	• inflammatory response • immune response • intracellular signaling cascade • cell-cell signaling • phosphorylation • leukocyte activation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_019009 (mRNA)
NP_061882 (protein)

NM_023764 (mRNA)
NP_076253 (protein)

Location

Chr 11: 1.25 - 1.29 Mb

Chr 7: 141.68 - 141.71 Mb

Pubmed search

[1]

[2]

Toll interacting protein, also known as TOLLIP, is a human gene.^[1]

[edit] References

^ Entrez Gene: TOLLIP toll interacting protein.

[edit] Further reading

Nilsen KH (1976). "Malignant lymphoma and rheumatic symptoms.". N. Z. Med. J. 83 (563): 320-2. PMID 1085432.
Volpe F, Clatworthy J, Kaptein A, et al. (1998). "The IL1 receptor accessory protein is responsible for the recruitment of the interleukin-1 receptor associated kinase to the IL1/IL1 receptor I complex.". FEBS Lett. 419 (1): 41-4. PMID 9426216.
Burns K, Clatworthy J, Martin L, et al. (2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor.". Nat. Cell Biol. 2 (6): 346-51. doi:10.1038/35014038. PMID 10854325.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Bulut Y, Faure E, Thomas L, et al. (2001). "Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling.". J. Immunol. 167 (2): 987-94. PMID 11441107.
Zhang G, Ghosh S (2002). "Negative regulation of toll-like receptor-mediated signaling by Tollip.". J. Biol. Chem. 277 (9): 7059-65. doi:10.1074/jbc.M109537200. PMID 11751856.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Yamakami M, Yoshimori T, Yokosawa H (2004). "Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin.". J. Biol. Chem. 278 (52): 52865-72. doi:10.1074/jbc.M306740200. PMID 14563850.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Katoh Y, Shiba Y, Mitsuhashi H, et al. (2004). "Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes.". J. Biol. Chem. 279 (23): 24435-43. doi:10.1074/jbc.M400059200. PMID 15047686.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315-23. doi:10.1101/gr.2122004. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Ohnuma K, Yamochi T, Uchiyama M, et al. (2005). "CD26 mediates dissociation of Tollip and IRAK-1 from caveolin-1 and induces upregulation of CD86 on antigen-presenting cells.". Mol. Cell. Biol. 25 (17): 7743-57. doi:10.1128/MCB.25.17.7743-7757.2005. PMID 16107720.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.
Katoh Y, Imakagura H, Futatsumori M, Nakayama K (2006). "Recruitment of clathrin onto endosomes by the Tom1-Tollip complex.". Biochem. Biophys. Res. Commun. 341 (1): 143-9. doi:10.1016/j.bbrc.2005.12.156. PMID 16412388.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801-14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Brissoni B, Agostini L, Kropf M, et al. (2007). "Intracellular trafficking of interleukin-1 receptor I requires Tollip.". Curr. Biol. 16 (22): 2265-70. doi:10.1016/j.cub.2006.09.062. PMID 17113392.