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| Tobamovirus internal ribosome entry site (IRES) |
 |
| Type: |
Cis-reg; IRES; |
| 2° structure: |
Published; PubMed |
| Seed alignment: |
[1] |
| Avg length: |
152.1 nucleotides |
| Avg identity: |
86% |
|
This family represents the Tobamovirus internal ribosome entry site (IRES).[1] IRES elements allow cap and end-independent translation of mRNA in the host cell. The IRES achieves this by mediating the internal initiation of translation by recruiting a ribosomal 43S pre-initiation complex directly to the initiation codon and eliminates the requirement for the eukaryotic initiation factor, eIF4F.[2]
[edit] References
- ^ Ivanov, PA; Karpova OV, Skulachev MV, Tomashevskaya OL, Rodionova NP, Dorokhov YuL, Atabekov JG (1997). "A tobamovirus genome that contains an internal ribosome entry site functional in vitro". Virology 232: 32–43. doi:10.1006/viro.1997.8525. PMID 9185586.
- ^ Kolupaeva, VG; Pestova TV, Hellen CU (2000). "Ribosomal binding to the internal ribosomal entry site of classical swine fever virus". RNA 6: 1791–1807. doi:10.1017/S1355838200000662. PMID 11142379.
[edit] External links
