TOB2

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Transducer of ERBB2, 2
Identifiers
Symbol(s) TOB2; TOB4; TOBL; TROB2
External IDs OMIM: 607396 MGI: 1888525 HomoloGene: 9447
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10766 57259
Ensembl ENSG00000183864 ENSMUSG00000048546
Uniprot Q14106 Q543X9
Refseq NM_016272 (mRNA)
NP_057356 (protein)		 NM_020507 (mRNA)
NP_065253 (protein)
Location Chr 22: 40.16 - 40.17 Mb Chr 15: 81.68 - 81.69 Mb
Pubmed search [1] [2]

Transducer of ERBB2, 2, also known as TOB2, is a human gene.[1]

TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: TOB2 transducer of ERBB2, 2.

[edit] Further reading

  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489-95. doi:10.1038/990031. PMID 10591208. 
  • Ikematsu N, Yoshida Y, Kawamura-Tsuzuku J, et al. (2000). "Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases.". Oncogene 18 (52): 7432-41. doi:10.1038/sj.onc.1203193. PMID 10602502. 
  • Hirosawa M, Nagase T, Murahashi Y, et al. (2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping.". DNA Res. 8 (1): 1-9. PMID 11258795. 
  • Suzuki T, Matsuda S, Tsuzuku JK, et al. (2001). "A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob.". Genes Cells 6 (2): 131-8. PMID 11260258. 
  • Yoshida Y, Hosoda E, Nakamura T, Yamamoto T (2001). "Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex.". Jpn. J. Cancer Res. 92 (6): 592-6. PMID 11429045. 
  • Sasajima H, Nakagawa K, Yokosawa H (2002). "Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system.". Eur. J. Biochem. 269 (14): 3596-604. PMID 12135500. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
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