TNPO2

From Wikipedia, the free encyclopedia

Transportin 2 (importin 3, karyopherin beta 2b)

Identifiers

TNPO2; FLJ12155; IPO3; KPNB2B; TRN2

External IDs

OMIM: 603002 MGI: 2384849 HomoloGene: 8381

Gene ontology
Molecular Function:	• binding • nuclear localization sequence binding • protein transporter activity
Cellular Component:	• nucleus • nuclear pore • cytoplasm
Biological Process:	• protein import into nucleus, docking • intracellular protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_013433 (mRNA)
NP_038461 (protein)

NM_145390 (mRNA)
NP_663365 (protein)

Location

Chr 19: 12.67 - 12.69 Mb

Chr 8: 87.93 - 87.95 Mb

Pubmed search

[1]

[2]

Transportin 2 (importin 3, karyopherin beta 2b), also known as TNPO2, is a human gene.^[1]

[edit] References

^ Entrez Gene: TNPO2 transportin 2 (importin 3, karyopherin beta 2b).

[edit] Further reading

Siomi MC, Eder PS, Kataoka N, et al. (1997). "Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins.". J. Cell Biol. 138 (6): 1181–92. PMID 9298975.
Gallouzi IE, Steitz JA (2001). "Delineation of mRNA export pathways by the use of cell-permeable peptides.". Science 294 (5548): 1895–901. doi:10.1126/science.1064693. PMID 11729309.
Shamsher MK, Ploski J, Radu A (2002). "Karyopherin beta 2B participates in mRNA export from the nucleus.". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14195–9. doi:10.1073/pnas.212518199. PMID 12384575.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Blanc V, Kennedy S, Davidson NO (2003). "A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling.". J. Biol. Chem. 278 (42): 41198–204. doi:10.1074/jbc.M302951200. PMID 12896982.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Güttinger S, Mühlhäusser P, Koller-Eichhorn R, et al. (2004). "Transportin2 functions as importin and mediates nuclear import of HuR.". Proc. Natl. Acad. Sci. U.S.A. 101 (9): 2918–23. doi:10.1073/pnas.0400342101. PMID 14981248.
Rebane A, Aab A, Steitz JA (2004). "Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR.". RNA 10 (4): 590–9. PMID 15037768.
Lee BJ, Cansizoglu AE, Süel KE, et al. (2006). "Rules for nuclear localization sequence recognition by karyopherin beta 2.". Cell 126 (3): 543–58. doi:10.1016/j.cell.2006.05.049. PMID 16901787.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.