TNP2

From Wikipedia, the free encyclopedia

Transition protein 2 (during histone to protamine replacement)

Identifiers

TNP2; MGC116783; MGC116785

External IDs

OMIM: 190232 MGI: 98785 HomoloGene: 3958

Gene ontology
Molecular Function:	• DNA binding • zinc ion binding • metal ion binding
Cellular Component:	• nucleosome • nucleus • chromosome
Biological Process:	• DNA packaging • chromosome organization and biogenesis (sensu Eukaryota) • multicellular organismal development • spermatogenesis • acrosome reaction • penetration of zona pellucida • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005425 (mRNA)
NP_005416 (protein)

NM_013694 (mRNA)
NP_038722 (protein)

Location

Chr 16: 11.27 - 11.27 Mb

Chr 16: 10.7 - 10.7 Mb

Pubmed search

[1]

[2]

Transition protein 2 (during histone to protamine replacement), also known as TNP2, is a human gene.^[1]

[edit] References

^ Entrez Gene: TNP2 transition protein 2 (during histone to protamine replacement).

[edit] Further reading

Schlüter G, Kremling H, Engel W (1992). "The gene for human transition protein 2: nucleotide sequence, assignment to the protamine gene cluster, and evidence for its low expression.". Genomics 14 (2): 377–83. PMID 1385303.
Engel W, Keime S, Kremling H, et al. (1992). "The genes for protamine 1 and 2 (PRM1 and PRM2) and transition protein 2 (TNP2) are closely linked in the mammalian genome.". Cytogenet. Cell Genet. 61 (2): 158–9. PMID 1395729.
Baskaran R, Rao MR (1991). "Interaction of spermatid-specific protein TP2 with nucleic acids, in vitro. A comparative study with TP1.". J. Biol. Chem. 265 (34): 21039–47. PMID 2250010.
Kundu TK, Rao MR (1995). "DNA condensation by the rat spermatidal protein TP2 shows GC-rich sequence preference and is zinc dependent.". Biochemistry 34 (15): 5143–50. PMID 7711033.
Nelson JE, Krawetz SA (1995). "Characterization of a human locus in transition.". J. Biol. Chem. 269 (49): 31067–73. PMID 7983046.
Nelson JE, Krawetz SA (1993). "Linkage of human spermatid-specific basic nuclear protein genes. Definition and evolution of the P1-->P2-->TP2 locus.". J. Biol. Chem. 268 (4): 2932–6. PMID 8428967.
Kundu TK, Rao MR (1997). "Zinc dependent recognition of a human CpG island sequence by the mammalian spermatidal protein TP2.". Biochemistry 35 (49): 15626–32. doi:10.1021/bi961271i. PMID 8961924.
Steger K, Klonisch T, Gavenis K, et al. (1999). "Expression of mRNA and protein of nucleoproteins during human spermiogenesis.". Mol. Hum. Reprod. 4 (10): 939–45. PMID 9809674.
Wyckoff GJ, Wang W, Wu CI (2000). "Rapid evolution of male reproductive genes in the descent of man.". Nature 403 (6767): 304–9. doi:10.1038/35002070. PMID 10659848.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Wykes SM, Krawetz SA (2003). "The structural organization of sperm chromatin.". J. Biol. Chem. 278 (32): 29471–7. doi:10.1074/jbc.M304545200. PMID 12775710.
Miyagawa Y, Nishimura H, Tsujimura A, et al. (2006). "Single-nucleotide polymorphisms and mutation analyses of the TNP1 and TNP2 genes of fertile and infertile human male populations.". J. Androl. 26 (6): 779–86. doi:10.2164/jandrol.05069. PMID 16291974.
Jedrzejczak P, Kempisty B, Bryja A, et al. (2007). "Quantitative assessment of transition proteins 1, 2 spermatid-specific linker histone H1-like protein transcripts in spermatozoa from normozoospermic and asthenozoospermic men.". Arch. Androl. 53 (4): 199–205. doi:10.1080/01485010701426430. PMID 17852044.