TNNC2

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Troponin C type 2 (fast)
PDB rendering based on 1a2x.
Available structures: 1a2x, 1avs, 1blq, 1ncx, 1ncy, 1ncz, 1npq, 1skt, 1smg, 1tcf, 1tn4, 1tnp, 1tnq, 1tnw, 1tnx, 1top, 1trf, 1ytz, 1yv0, 1zac, 2tn4, 4tnc, 5tnc
Identifiers
Symbol(s) TNNC2;
External IDs OMIM: 191039 MGI: 98780 HomoloGene: 55727
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 7125 21925
Ensembl ENSG00000101470 ENSMUSG00000017300
Uniprot P02585 Q3UZY7
Refseq NM_003279 (mRNA)
NP_003270 (protein)		 NM_009394 (mRNA)
NP_033420 (protein)
Location Chr 20: 43.89 - 43.9 Mb Chr 2: 164.47 - 164.47 Mb
Pubmed search [1] [2]

Troponin C type 2 (fast), also known as TNNC2, is a human gene.[1]

Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit.[1]

[edit] References

  1. ^ a b Entrez Gene: TNNC2 troponin C type 2 (fast).

[edit] Further reading

  • Romero-Herrera AE, Castillo O, Lehmann H (1977). "Human skeletal muscle proteins. The primary structure of troponin C.". J. Mol. Evol. 8 (3): 251-70. PMID 978749. 
  • Tomasselli AG, Hui JO, Adams L, et al. (1991). "Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus.". J. Biol. Chem. 266 (22): 14548-53. PMID 1907279. 
  • Gahlmann R, Kedes L (1990). "Cloning, structural analysis, and expression of the human fast twitch skeletal muscle troponin C gene.". J. Biol. Chem. 265 (21): 12520-8. PMID 2373703. 
  • Gahlmann R, Wade R, Gunning P, Kedes L (1988). "Differential expression of slow and fast skeletal muscle troponin C. Slow skeletal muscle troponin C is expressed in human fibroblasts.". J. Mol. Biol. 201 (2): 379-91. PMID 3166492. 
  • Prentice H, Kloner RA, Prigozy T, et al. (1995). "Tissue restricted gene expression assayed by direct DNA injection into cardiac and skeletal muscle.". J. Mol. Cell. Cardiol. 26 (10): 1393-401. doi:10.1006/jmcc.1994.1157. PMID 7869399. 
  • Tiso N, Rampoldi L, Pallavicini A, et al. (1997). "Fine mapping of five human skeletal muscle genes: alpha-tropomyosin, beta-tropomyosin, troponin-I slow-twitch, troponin-I fast-twitch, and troponin-C fast.". Biochem. Biophys. Res. Commun. 230 (2): 347-50. doi:10.1006/bbrc.1996.5958. PMID 9016781. 
  • Townsend PJ, Yacoub MH, Barton PJ (1998). "Assignment of the human fast skeletal muscle troponin C gene (TNNC2) between D20S721 and GCT10F11 on chromosome 20 by somatic cell hybrid analysis.". Ann. Hum. Genet. 61 (Pt 5): 457-9. doi:10.1046/j.1469-1809.1997.6150457.x. PMID 9459007. 
  • Vassylyev DG, Takeda S, Wakatsuki S, et al. (1998). "Crystal structure of troponin C in complex with troponin I fragment at 2.3-A resolution.". Proc. Natl. Acad. Sci. U.S.A. 95 (9): 4847-52. PMID 9560191. 
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
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