TNFSF12-TNFSF13

From Wikipedia, the free encyclopedia

Tumor necrosis factor (ligand) superfamily, member 12-member 13

Identifiers

External IDs

Gene ontology
Molecular Function:	• tumor necrosis factor receptor binding
Cellular Component:	• membrane
Biological Process:	• immune response

Orthologs

Human

Mouse

Entrez

407977

619441

Refseq

NM_172089 (mRNA)
NP_742086 (protein)

NM_001034097 (mRNA)
NP_001029269 (protein)

Pubmed search

[1]

[2]

Tumor necrosis factor (ligand) superfamily, member 12-member 13, also known as TNFSF12-TNFSF13, is a human gene.^[1]

This gene belongs to the tumor necrosis factor superfamily (TNFSF). It encodes a hybrid protein composed of the cytoplasmic and transmembrane domains of the family member 12 fused to the C-terminal domain of the family member 13. The hybrid protein is membrane anchored and presents the receptor-binding domain of the family member 13 at the cell surface. It stimulates cycling in T- and B-lymphoma cell lines. The mRNA transcript is expressed and translated in primary T cells and monocytes.^[1]

[edit] References

^ ^a ^b Entrez Gene: TNFSF12-TNFSF13 tumor necrosis factor (ligand) superfamily, member 12-member 13.

[edit] Further reading

Hahne M, Kataoka T, Schröter M, et al. (1998). "APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth.". J. Exp. Med. 188 (6): 1185-90. PMID 9743536.
Kelly K, Manos E, Jensen G, et al. (2000). "APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death.". Cancer Res. 60 (4): 1021-7. PMID 10706119.
Wu Y, Bressette D, Carrell JA, et al. (2001). "Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS.". J. Biol. Chem. 275 (45): 35478-85. doi:10.1074/jbc.M005224200. PMID 10956646.
Yu G, Boone T, Delaney J, et al. (2001). "APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity.". Nat. Immunol. 1 (3): 252-6. doi:10.1038/79802. PMID 10973284.
Gallouzi IE, Brennan CM, Steitz JA (2001). "Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock.". RNA 7 (9): 1348-61. PMID 11565755.
López-Fraga M, Fernández R, Albar JP, Hahne M (2002). "Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase.". EMBO Rep. 2 (10): 945-51. doi:10.1093/embo-reports/kve198. PMID 11571266.
Roschke V, Sosnovtseva S, Ward CD, et al. (2002). "BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases.". J. Immunol. 169 (8): 4314-21. PMID 12370363.
Pradet-Balade B, Medema JP, López-Fraga M, et al. (2002). "An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein.". EMBO J. 21 (21): 5711-20. PMID 12411489.
Hendriks J, Planelles L, de Jong-Odding J, et al. (2005). "Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation.". Cell Death Differ. 12 (6): 637-48. doi:10.1038/sj.cdd.4401647. PMID 15846369.