TNFRSF6B

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Tumor necrosis factor receptor superfamily, member 6b, decoy
Identifiers
Symbol(s) TNFRSF6B; DCR3; DJ583P15.1.1; M68; TR6
External IDs OMIM: 603361 HomoloGene: 48242
Orthologs
Human Mouse
Entrez 8771 n/a


Refseq NM_003823 (mRNA)
NP_003814 (protein)		 n/a (mRNA)
n/a (protein)
Pubmed search [1] n/a

Tumor necrosis factor receptor superfamily, member 6b, decoy, also known as TNFRSF6B, is a human gene.[1]

This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Overexpression of this gene has been noted in gastrointestinal tract tumors, and it is located in a gene-rich cluster on chromosome 20, with other potentially tumor-related genes. Two transcript variants encoding the same isoform, but differing in the 5' UTR, have been observed for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy.

[edit] Further reading

  • Pitti RM, Marsters SA, Lawrence DA, et al. (1999). "Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer.". Nature 396 (6712): 699–703. doi:10.1038/25387. PMID 9872321. 
  • Yu KY, Kwon B, Ni J, et al. (1999). "A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis.". J. Biol. Chem. 274 (20): 13733–6. PMID 10318773. 
  • Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (3): 197–205. PMID 10470851. 
  • Bai C, Connolly B, Metzker ML, et al. (2000). "Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster.". Proc. Natl. Acad. Sci. U.S.A. 97 (3): 1230–5. PMID 10655513. 
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. 
  • Migone TS, Zhang J, Luo X, et al. (2002). "TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator.". Immunity 16 (3): 479–92. PMID 11911831. 
  • Hsu TL, Chang YC, Chen SJ, et al. (2002). "Modulation of dendritic cell differentiation and maturation by decoy receptor 3.". J. Immunol. 168 (10): 4846–53. PMID 11994433. 
  • Mild G, Bachmann F, Boulay JL, et al. (2002). "DCR3 locus is a predictive marker for 5-fluorouracil-based adjuvant chemotherapy in colorectal cancer.". Int. J. Cancer 102 (3): 254–7. doi:10.1002/ijc.10711. PMID 12397645. 
  • Gill RM, Ni J, Hunt JS (2003). "Differential expression of LIGHT and its receptors in human placental villi and amniochorion membranes.". Am. J. Pathol. 161 (6): 2011–7. PMID 12466117. 
  • Wan X, Zhang J, Luo H, et al. (2003). "A TNF family member LIGHT transduces costimulatory signals into human T cells.". J. Immunol. 169 (12): 6813–21. PMID 12471113. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Wan X, Shi G, Semenuk M, et al. (2003). "DcR3/TR6 modulates immune cell interactions.". J. Cell. Biochem. 89 (3): 603–12. doi:10.1002/jcb.10523. PMID 12761893. 
  • Tsuji S, Hosotani R, Yonehara S, et al. (2003). "Endogenous decoy receptor 3 blocks the growth inhibition signals mediated by Fas ligand in human pancreatic adenocarcinoma.". Int. J. Cancer 106 (1): 17–25. doi:10.1002/ijc.11170. PMID 12794752. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Shi G, Wu Y, Zhang J, Wu J (2004). "Death decoy receptor TR6/DcR3 inhibits T cell chemotaxis in vitro and in vivo.". J. Immunol. 171 (7): 3407–14. PMID 14500635. 
  • Wu SF, Liu TM, Lin YC, et al. (2004). "Immunomodulatory effect of decoy receptor 3 on the differentiation and function of bone marrow-derived dendritic cells in nonobese diabetic mice: from regulatory mechanism to clinical implication.". J. Leukoc. Biol. 75 (2): 293–306. doi:10.1189/jlb.0303119. PMID 14634066. 
  • Chang YC, Hsu TL, Lin HH, et al. (2004). "Modulation of macrophage differentiation and activation by decoy receptor 3.". J. Leukoc. Biol. 75 (3): 486–94. doi:10.1189/jlb.0903448. PMID 14657214. 
  • Kim S, McAuliffe WJ, Zaritskaya LS, et al. (2004). "Selective induction of tumor necrosis receptor factor 6/decoy receptor 3 release by bacterial antigens in human monocytes and myeloid dendritic cells.". Infect. Immun. 72 (1): 89–93. PMID 14688085. 
  • Hsu MJ, Lin WW, Tsao WC, et al. (2004). "Enhanced adhesion of monocytes via reverse signaling triggered by decoy receptor 3.". Exp. Cell Res. 292 (2): 241–51. PMID 14697332. 
  • Gill RM, Hunt JS (2004). "Soluble receptor (DcR3) and cellular inhibitor of apoptosis-2 (cIAP-2) protect human cytotrophoblast cells against LIGHT-mediated apoptosis.". Am. J. Pathol. 165 (1): 309–17. PMID 15215185. 
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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