TNFRSF21

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Tumor necrosis factor receptor superfamily, member 21
PDB rendering based on 2dbh.
Available structures: 2dbh
Identifiers
Symbol(s) TNFRSF21; BM-018; DR6; MGC31965
External IDs OMIM: 605732 MGI: 2151075 HomoloGene: 8696
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 27242 94185
Ensembl ENSG00000146072 ENSMUSG00000023915
Uniprot O75509 Q3UPV2
Refseq NM_014452 (mRNA)
NP_055267 (protein)		 NM_178589 (mRNA)
NP_848704 (protein)
Location Chr 6: 47.31 - 47.39 Mb Chr 17: 42.48 - 42.55 Mb
Pubmed search [1] [2]

Tumor necrosis factor receptor superfamily, member 21, also known as TNFRSF21, is a human gene.[1]

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB and MAPK8/JNK, and induce cell apoptosis. Through its death domain, this receptor interacts with TRADD protein, which is known to serve as an adaptor that mediates signal transduction of TNF-receptors. Knockout studies in mice suggested that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation.[1]

[edit] References

  1. ^ a b Entrez Gene: TNFRSF21 tumor necrosis factor receptor superfamily, member 21.

[edit] Further reading

  • Pan G, Bauer JH, Haridas V, et al. (1998). "Identification and functional characterization of DR6, a novel death domain-containing TNF receptor.". FEBS Lett. 431 (3): 351-6. PMID 9714541. 
  • Liu J, Na S, Glasebrook A, et al. (2001). "Enhanced CD4+ T cell proliferation and Th2 cytokine production in DR6-deficient mice.". Immunity 15 (1): 23-34. PMID 11485735. 
  • Zhao H, Yan M, Wang H, et al. (2001). "Impaired c-Jun amino terminal kinase activity and T cell differentiation in death receptor 6-deficient mice.". J. Exp. Med. 194 (10): 1441-8. PMID 11714751. 
  • Kasof GM, Lu JJ, Liu D, et al. (2002). "Tumor necrosis factor-alpha induces the expression of DR6, a member of the TNF receptor family, through activation of NF-kappaB.". Oncogene 20 (55): 7965-75. doi:10.1038/sj.onc.1204985. PMID 11753679. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Mai T, Wang X, Zhang Z, et al. (2005). "Androgen receptor coregulator ARA267-alpha interacts with death receptor-6 revealed by the yeast two-hybrid.". Sci. China, C, Life Sci. 47 (5): 442-8. PMID 15623156. 
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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Cytokine receptors: tumor necrosis factor receptor superfamily
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