TNFRSF19

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Tumor necrosis factor receptor superfamily, member 19
Identifiers
Symbol(s) TNFRSF19; TAJ; TAJ-alpha; TRADE; TROY
External IDs OMIM: 606122 MGI: 1352474 HomoloGene: 8481
Orthologs
Human Mouse
Entrez 55504 29820
Ensembl ENSG00000127863 ENSMUSG00000060548
Uniprot Q9NS68 Q80T13
Refseq NM_018647 (mRNA)
NP_061117 (protein)		 NM_013869 (mRNA)
NP_038897 (protein)
Location Chr 13: 23.04 - 23.15 Mb Chr 14: 59.92 - 59.98 Mb
Pubmed search [1] [2]

Tumor necrosis factor receptor superfamily, member 19, also known as TNFRSF19, is a human gene.[1]

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described.[1]

[edit] References

  1. ^ a b Entrez Gene: TNFRSF19 tumor necrosis factor receptor superfamily, member 19.

[edit] Further reading

  • Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101. 
  • Kojima T, Morikawa Y, Copeland NG, et al. (2000). "TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles.". J. Biol. Chem. 275 (27): 20742–7. doi:10.1074/jbc.M002691200. PMID 10764796. 
  • Eby MT, Jasmin A, Kumar A, et al. (2000). "TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death.". J. Biol. Chem. 275 (20): 15336–42. PMID 10809768. 
  • Naito A, Yoshida H, Nishioka E, et al. (2002). "TRAF6-deficient mice display hypohidrotic ectodermal dysplasia.". Proc. Natl. Acad. Sci. U.S.A. 99 (13): 8766–71. doi:10.1073/pnas.132636999. PMID 12060722. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Park JB, Yiu G, Kaneko S, et al. (2005). "A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors.". Neuron 45 (3): 345–51. doi:10.1016/j.neuron.2004.12.040. PMID 15694321. 
  • Shao Z, Browning JL, Lee X, et al. (2005). "TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration.". Neuron 45 (3): 353–9. doi:10.1016/j.neuron.2004.12.050. PMID 15694322. 
  • Spanjaard RA, Whren KM, Graves C, Bhawan J (2007). "Tumor necrosis factor receptor superfamily member TROY is a novel melanoma biomarker and potential therapeutic target.". Int. J. Cancer 120 (6): 1304–10. doi:10.1002/ijc.22367. PMID 17187358. 
  • Satoh J, Tabunoki H, Yamamura T, et al. (2007). "TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions.". Neuropathol. Appl. Neurobiol. 33 (1): 99–107. doi:10.1111/j.1365-2990.2006.00787.x. PMID 17239012. 
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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