TNFRSF17

From Wikipedia, the free encyclopedia


Tumor necrosis factor receptor superfamily, member 17
PDB rendering based on 1oqd.
Available structures: 1oqd, 1xu2
Identifiers
Symbol(s) TNFRSF17; BCM; BCMA; CD269
External IDs OMIM: 109545 MGI: 1343050 HomoloGene: 920
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 608 21935
Ensembl ENSG00000048462 ENSMUSG00000022496
Uniprot Q02223 O88472
Refseq NM_001192 (mRNA)
NP_001183 (protein)		 NM_011608 (mRNA)
NP_035738 (protein)
Location Chr 16: 11.97 - 11.97 Mb Chr 16: 11.23 - 11.23 Mb
Pubmed search [1] [2]

Tumor necrosis factor receptor superfamily, member 17, also known as TNFRSF17, is a human gene.[1]

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.[1]

[edit] References

  1. ^ a b Entrez Gene: TNFRSF17 tumor necrosis factor receptor superfamily, member 17.

[edit] Further reading

  • Treml LS, Crowley JE, Cancro MP (2007). "BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells.". Semin. Immunol. 18 (5): 297–304. doi:10.1016/j.smim.2006.07.001. PMID 16919470. 
  • Mackay F, Leung H (2007). "The role of the BAFF/APRIL system on T cell function.". Semin. Immunol. 18 (5): 284–9. doi:10.1016/j.smim.2006.04.005. PMID 16931039. 
  • Laâbi Y, Gras MP, Carbonnel F, et al. (1992). "A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma.". EMBO J. 11 (11): 3897–904. PMID 1396583. 
  • Laabi Y, Gras MP, Brouet JC, et al. (1994). "The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed.". Nucleic Acids Res. 22 (7): 1147–54. PMID 8165126. 
  • Gras MP, Laâbi Y, Linares-Cruz G, et al. (1996). "BCMAp: an integral membrane protein in the Golgi apparatus of human mature B lymphocytes.". Int. Immunol. 7 (7): 1093–106. PMID 8527407. 
  • Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.". Genomics 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829. 
  • Gross JA, Johnston J, Mudri S, et al. (2000). "TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease.". Nature 404 (6781): 995–9. doi:10.1038/35010115. PMID 10801128. 
  • Hatzoglou A, Roussel J, Bourgeade MF, et al. (2000). "TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase.". J. Immunol. 165 (3): 1322–30. PMID 10903733. 
  • Shu HB, Johnson H (2000). "B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1.". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9156–61. doi:10.1073/pnas.160213497. PMID 10908663. 
  • Yu G, Boone T, Delaney J, et al. (2001). "APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity.". Nat. Immunol. 1 (3): 252–6. doi:10.1038/79802. PMID 10973284. 
  • Kawasaki A, Tsuchiya N, Fukazawa T, et al. (2001). "Presence of four major haplotypes in human BCMA gene: lack of association with systemic lupus erythematosus and rheumatoid arthritis.". Genes Immun. 2 (5): 276–9. doi:10.1038/sj.gene.6363770. PMID 11528522. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Novak AJ, Darce JR, Arendt BK, et al. (2004). "Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival.". Blood 103 (2): 689–94. doi:10.1182/blood-2003-06-2043. PMID 14512299. 
  • Hymowitz SG, Patel DR, Wallweber HJ, et al. (2005). "Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding.". J. Biol. Chem. 280 (8): 7218–27. doi:10.1074/jbc.M411714200. PMID 15542592. 
  • Bellucci R, Alyea EP, Chiaretti S, et al. (2005). "Graft-versus-tumor response in patients with multiple myeloma is associated with antibody response to BCMA, a plasma-cell membrane receptor.". Blood 105 (10): 3945–50. doi:10.1182/blood-2004-11-4463. PMID 15692072. 
  • Hendriks J, Planelles L, de Jong-Odding J, et al. (2005). "Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation.". Cell Death Differ. 12 (6): 637–48. doi:10.1038/sj.cdd.4401647. PMID 15846369. 
  • Chiu A, Xu W, He B, et al. (2007). "Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL.". Blood 109 (2): 729–39. doi:10.1182/blood-2006-04-015958. PMID 16960154. 
  • Smirnova AS, Andrade-Oliveira V, Gerbase-Delima M. "Identification of new splice variants of the genes BAFF and BCMA." 45 (4): 1179–1183. doi:10.1016/j.molimm.2007.07.028. PMID 17825416. 
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50
CD1 (a-c, 1A, 1D, 1E) - CD2 - CD3 (γ, δ, ε) - CD4 - CD5 - CD6 - CD7 - CD8 (a) - CD9 - CD10 - CD11 (a, b, c) - CD13 - CD14 - CD15 - CD16 (A, B) - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 (A, B) - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 (a, b, c, d) - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 (a, b, c, d, e, f) - CD50
51-100
CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 (E, L, P) - CD63 - CD64 - CD66 (a, b, c, d, e, f) - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 (a, b) - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 (a, d, e, h, j, k) - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100
101-150
CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 (a, b) - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 (a, b) - CD121 (a, b) - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150
151-200
CD151 - CD152 - CD153 - CD154 - CD155 - CD156 (a, b, c) - CD157 - CD158 (a, d, e, i, k) - CD159 (a, c) - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 (a, b) - CD168 - CD169 - CD170 - CD171 - CD172 (a, b, g) - CD174 - CD177 - CD178 - CD179 (a, b) - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200
201-250
CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 (a, b) - CD212 - CD213a (1, 2) - CD217 - CD218 (a, b) - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 (a, b) - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249
251-300
301-350
v • d • e
Cytokine receptors: tumor necrosis factor receptor superfamily
1-10
11-20
21-25