TNFRSF12A

From Wikipedia, the free encyclopedia


Tumor necrosis factor receptor superfamily, member 12A
Identifiers
Symbol(s) TNFRSF12A; CD266; FN14; TWEAKR
External IDs OMIM: 605914 MGI: 1351484 HomoloGene: 8451
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 51330 27279
Ensembl ENSG00000006327 ENSMUSG00000023905
Uniprot Q9NP84 Q9CR75
Refseq NM_016639 (mRNA)
NP_057723 (protein)		 NM_013749 (mRNA)
NP_038777 (protein)
Location Chr 16: 3.01 - 3.01 Mb Chr 17: 23.4 - 23.41 Mb
Pubmed search [1] [2]

Tumor necrosis factor receptor superfamily, member 12A, also known as TNFRSF12A, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: TNFRSF12A tumor necrosis factor receptor superfamily, member 12A.

[edit] Further reading

  • Campbell S, Michaelson J, Burkly L, Putterman C (2006). "The role of TWEAK/Fn14 in the pathogenesis of inflammation and systemic autoimmunity.". Front. Biosci. 9: 2273-84. PMID 15353286. 
  • Meighan-Mantha RL, Hsu DK, Guo Y, et al. (2000). "The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration.". J. Biol. Chem. 274 (46): 33166-76. PMID 10551889. 
  • Feng SL, Guo Y, Factor VM, et al. (2000). "The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas.". Am. J. Pathol. 156 (4): 1253-61. PMID 10751351. 
  • Wiley SR, Cassiano L, Lofton T, et al. (2001). "A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis.". Immunity 15 (5): 837-46. PMID 11728344. 
  • Harada N, Nakayama M, Nakano H, et al. (2003). "Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells.". Biochem. Biophys. Res. Commun. 299 (3): 488-93. PMID 12445828. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Nakayama M, Ishidoh K, Kojima Y, et al. (2003). "Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death.". J. Immunol. 170 (1): 341-8. PMID 12496418. 
  • Tran NL, McDonough WS, Donohue PJ, et al. (2003). "The human Fn14 receptor gene is up-regulated in migrating glioma cells in vitro and overexpressed in advanced glial tumors.". Am. J. Pathol. 162 (4): 1313-21. PMID 12651623. 
  • Tanabe K, Bonilla I, Winkles JA, Strittmatter SM (2003). "Fibroblast growth factor-inducible-14 is induced in axotomized neurons and promotes neurite outgrowth.". J. Neurosci. 23 (29): 9675-86. PMID 14573547. 
  • Jin L, Nakao A, Nakayama M, et al. (2004). "Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes.". J. Invest. Dermatol. 122 (5): 1175-9. doi:10.1111/j.0022-202X.2004.22419.x. PMID 15140220. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Tran NL, McDonough WS, Savitch BA, et al. (2005). "The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling system regulates glioma cell survival via NFkappaB pathway activation and BCL-XL/BCL-W expression.". J. Biol. Chem. 280 (5): 3483-92. doi:10.1074/jbc.M409906200. PMID 15611130. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Chacón MR, Richart C, Gómez JM, et al. (2006). "Expression of TWEAK and its receptor Fn14 in human subcutaneous adipose tissue. Relationship with other inflammatory cytokines in obesity.". Cytokine 33 (3): 129-37. doi:10.1016/j.cyto.2005.12.005. PMID 16503147. 
  • Brown SA, Hanscom HN, Vu H, et al. (2006). "TWEAK binding to the Fn14 cysteine-rich domain depends on charged residues located in both the A1 and D2 modules.". Biochem. J. 397 (2): 297-304. doi:10.1042/BJ20051362. PMID 16526941. 
  • Muñoz-García B, Martín-Ventura JL, Martínez E, et al. (2006). "Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: modulation by atorvastatin.". Stroke 37 (8): 2044-53. doi:10.1161/01.STR.0000230648.00027.00. PMID 16809572. 
  • Tran NL, McDonough WS, Savitch BA, et al. (2007). "Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome.". Cancer Res. 66 (19): 9535-42. doi:10.1158/0008-5472.CAN-06-0418. PMID 17018610. 
  • Girgenrath M, Weng S, Kostek CA, et al. (2007). "TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration.". EMBO J. 25 (24): 5826-39. doi:10.1038/sj.emboj.7601441. PMID 17124496. 
  • Dogra C, Hall SL, Wedhas N, et al. (2007). "Fibroblast growth factor inducible 14 (Fn14) is required for the expression of myogenic regulatory factors and differentiation of myoblasts into myotubes. Evidence for TWEAK-independent functions of Fn14 during myogenesis.". J. Biol. Chem. 282 (20): 15000-10. doi:10.1074/jbc.M608668200. PMID 17383968. 
 This membrane protein-related article is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50
CD1 (a-c, 1A, 1D, 1E) - CD2 - CD3 (γ, δ, ε) - CD4 - CD5 - CD6 - CD7 - CD8 (a) - CD9 - CD10 - CD11 (a, b, c) - CD13 - CD14 - CD15 - CD16 (A, B) - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 (A, B) - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 (a, b, c, d) - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 (a, b, c, d, e, f) - CD50
51-100
CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 (E, L, P) - CD63 - CD64 - CD66 (a, b, c, d, e, f) - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 (a, b) - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 (a, d, e, h, j, k) - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100
101-150
CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 (a, b) - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 (a, b) - CD121 (a, b) - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150
151-200
CD151 - CD152 - CD153 - CD154 - CD155 - CD156 (a, b, c) - CD157 - CD158 (a, d, e, i, k) - CD159 (a, c) - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 (a, b) - CD168 - CD169 - CD170 - CD171 - CD172 (a, b, g) - CD174 - CD177 - CD178 - CD179 (a, b) - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200
201-250
CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 (a, b) - CD212 - CD213a (1, 2) - CD217 - CD218 (a, b) - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 (a, b) - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249
251-300
301-350
v • d • e
Cytokine receptors: tumor necrosis factor receptor superfamily
1-10
11-20
21-25