TNFRSF10B

From Wikipedia, the free encyclopedia

Tumor necrosis factor receptor superfamily, member 10b
PDB rendering based on 1d0g.
Available structures: 1d0g, 1d4v, 1du3, 1za3, 2h9g
Identifiers
Symbol(s) TNFRSF10B; CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9
External IDs OMIM: 603612 HomoloGene: 88698
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 8795 n/a
Ensembl ENSG00000120889 n/a
Uniprot O14763 n/a
Refseq NM_003842 (mRNA)
NP_003833 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 8: 22.93 - 22.98 Mb n/a
Pubmed search [1] n/a

Tumor necrosis factor receptor superfamily, member 10b, also known as TNFRSF10B, is a human gene.

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracelluar death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. Mice have a homologous gene, tnfrsf10b, that has been essential in the elucidation of the function of this gene in humans. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.[1]

Contents

[edit] See also

[edit] References

  1. ^ Entrez Gene: TNFRSF10B tumor necrosis factor receptor superfamily, member 10b.

[edit] Further reading

  • Abe K, Kurakin A, Mohseni-Maybodi M, et al. (2001). "The complexity of TNF-related apoptosis-inducing ligand.". Ann. N. Y. Acad. Sci. 926: 52–63. PMID 11193041. 
  • Cha SS, Song YL, Oh BH (2004). "Specificity of molecular recognition learned from the crystal structures of TRAIL and the TRAIL:sDR5 complex.". Vitam. Horm. 67: 1–17. doi:10.1016/S0083-6729(04)67001-4. PMID 15110168. 
  • Kimberley FC, Screaton GR (2005). "Following a TRAIL: update on a ligand and its five receptors.". Cell Res. 14 (5): 359–72. doi:10.1038/sj.cr.7290236. PMID 15538968. 
  • Pan G, Ni J, Wei YF, et al. (1997). "An antagonist decoy receptor and a death domain-containing receptor for TRAIL.". Science 277 (5327): 815–8. PMID 9242610. 
  • Sheridan JP, Marsters SA, Pitti RM, et al. (1997). "Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors.". Science 277 (5327): 818–21. PMID 9242611. 
  • Screaton GR, Mongkolsapaya J, Xu XN, et al. (1998). "TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL.". Curr. Biol. 7 (9): 693–6. PMID 9285725. 
  • Walczak H, Degli-Esposti MA, Johnson RS, et al. (1997). "TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.". EMBO J. 16 (17): 5386–97. doi:10.1093/emboj/16.17.5386. PMID 9311998. 
  • MacFarlane M, Ahmad M, Srinivasula SM, et al. (1997). "Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL.". J. Biol. Chem. 272 (41): 25417–20. PMID 9325248. 
  • Wu GS, Burns TF, McDonald ER, et al. (1997). "KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene.". Nat. Genet. 17 (2): 141–3. doi:10.1038/ng1097-141. PMID 9326928. 
  • Schneider P, Bodmer JL, Thome M, et al. (1997). "Characterization of two receptors for TRAIL.". FEBS Lett. 416 (3): 329–34. PMID 9373179. 
  • Marsters SA, Sheridan JP, Pitti RM, et al. (1998). "A novel receptor for Apo2L/TRAIL contains a truncated death domain.". Curr. Biol. 7 (12): 1003–6. PMID 9382840. 
  • Chaudhary PM, Eby M, Jasmin A, et al. (1998). "Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway.". Immunity 7 (6): 821–30. PMID 9430227. 
  • Schneider P, Thome M, Burns K, et al. (1998). "TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB.". Immunity 7 (6): 831–6. PMID 9430228. 
  • Pai SI, Wu GS, Ozören N, et al. (1998). "Rare loss-of-function mutation of a death receptor gene in head and neck cancer.". Cancer Res. 58 (16): 3513–8. PMID 9721851. 
  • Arai T, Akiyama Y, Okabe S, et al. (1999). "Genomic organization and mutation analyses of the DR5/TRAIL receptor 2 gene in colorectal carcinomas.". Cancer Lett. 133 (2): 197–204. PMID 10072170. 
  • Mongkolsapaya J, Grimes JM, Chen N, et al. (2002). "Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation.". Nat. Struct. Biol. 6 (11): 1048–53. doi:10.1038/14935. PMID 10542098. 
  • Hymowitz SG, Christinger HW, Fuh G, et al. (1999). "Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5.". Mol. Cell 4 (4): 563–71. PMID 10549288. 
  • Kuang AA, Diehl GE, Zhang J, Winoto A (2000). "FADD is required for DR4- and DR5-mediated apoptosis: lack of trail-induced apoptosis in FADD-deficient mouse embryonic fibroblasts.". J. Biol. Chem. 275 (33): 25065–8. doi:10.1074/jbc.C000284200. PMID 10862756. 
  • Trauzold A, Wermann H, Arlt A, et al. (2001). "CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells.". Oncogene 20 (31): 4258–69. doi:10.1038/sj.onc.1204559. PMID 11464292. 

[edit] External links

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v • d • e
Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50
CD1 (a-c, 1A, 1D, 1E) - CD2 - CD3 (γ, δ, ε) - CD4 - CD5 - CD6 - CD7 - CD8 (a) - CD9 - CD10 - CD11 (a, b, c) - CD13 - CD14 - CD15 - CD16 (A, B) - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 (A, B) - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 (a, b, c, d) - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 (a, b, c, d, e, f) - CD50
51-100
CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 (E, L, P) - CD63 - CD64 - CD66 (a, b, c, d, e, f) - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 (a, b) - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 (a, d, e, h, j, k) - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100
101-150
CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 (a, b) - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 (a, b) - CD121 (a, b) - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150
151-200
CD151 - CD152 - CD153 - CD154 - CD155 - CD156 (a, b, c) - CD157 - CD158 (a, d, e, i, k) - CD159 (a, c) - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 (a, b) - CD168 - CD169 - CD170 - CD171 - CD172 (a, b, g) - CD174 - CD177 - CD178 - CD179 (a, b) - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200
201-250
CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 (a, b) - CD212 - CD213a (1, 2) - CD217 - CD218 (a, b) - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 (a, b) - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249
251-300
301-350
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Cytokine receptors: tumor necrosis factor receptor superfamily
1-10
11-20
21-25