TNFRSF10A
From Wikipedia, the free encyclopedia
|
Tumor necrosis factor receptor superfamily, member 10a
|
||||||||||||||
| Identifiers | ||||||||||||||
| Symbol(s) | TNFRSF10A; APO2; CD261; DR4; MGC9365; TRAILR-1; TRAILR1 | |||||||||||||
| External IDs | OMIM: 603611 MGI: 1341090 HomoloGene: 48245 | |||||||||||||
|
||||||||||||||
| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 8797 | 21933 | ||||||||||||
| Ensembl | ENSG00000104689 | ENSMUSG00000022074 | ||||||||||||
| Uniprot | O00220 | Q6GSD9 | ||||||||||||
| Refseq | NM_003844 (mRNA) NP_003835 (protein) |
NM_020275 (mRNA) NP_064671 (protein) |
||||||||||||
| Location | Chr 8: 23.1 - 23.14 Mb | Chr 14: 68.5 - 68.52 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Tumor necrosis factor receptor superfamily, member 10a, also known as TNFRSF10A, is a human gene.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.[1]
[edit] References
[edit] Further reading
- Kimberley FC, Screaton GR (2005). "Following a TRAIL: update on a ligand and its five receptors.". Cell Res. 14 (5): 359–72. doi:. PMID 15538968.
- Fleury S, Thibodeau J, Croteau G, et al. (1995). "HLA-DR polymorphism affects the interaction with CD4.". J. Exp. Med. 182 (3): 733–41. PMID 7650480.
- Pan G, O'Rourke K, Chinnaiyan AM, et al. (1997). "The receptor for the cytotoxic ligand TRAIL.". Science 276 (5309): 111–3. PMID 9082980.
- Walczak H, Degli-Esposti MA, Johnson RS, et al. (1997). "TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.". EMBO J. 16 (17): 5386–97. doi:. PMID 9311998.
- MacFarlane M, Ahmad M, Srinivasula SM, et al. (1997). "Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL.". J. Biol. Chem. 272 (41): 25417–20. PMID 9325248.
- Schneider P, Bodmer JL, Thome M, et al. (1997). "Characterization of two receptors for TRAIL.". FEBS Lett. 416 (3): 329–34. PMID 9373179.
- Marsters SA, Sheridan JP, Pitti RM, et al. (1998). "A novel receptor for Apo2L/TRAIL contains a truncated death domain.". Curr. Biol. 7 (12): 1003–6. PMID 9382840.
- Chaudhary PM, Eby M, Jasmin A, et al. (1998). "Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway.". Immunity 7 (6): 821–30. PMID 9430227.
- Schneider P, Thome M, Burns K, et al. (1998). "TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB.". Immunity 7 (6): 831–6. PMID 9430228.
- Diab BY, Lambert NC, L'Faqihi FE, et al. (1999). "Human collagen II peptide 256-271 preferentially binds to HLA-DR molecules associated with susceptibility to rheumatoid arthritis.". Immunogenetics 49 (1): 36–44. PMID 9811967.
- Costanzo A, Guiet C, Vito P (1999). "c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB.". J. Biol. Chem. 274 (29): 20127–32. PMID 10400625.
- Hymowitz SG, Christinger HW, Fuh G, et al. (1999). "Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5.". Mol. Cell 4 (4): 563–71. PMID 10549288.
- Gibson SB, Oyer R, Spalding AC, et al. (2000). "Increased expression of death receptors 4 and 5 synergizes the apoptosis response to combined treatment with etoposide and TRAIL.". Mol. Cell. Biol. 20 (1): 205–12. PMID 10594023.
- Kuang AA, Diehl GE, Zhang J, Winoto A (2000). "FADD is required for DR4- and DR5-mediated apoptosis: lack of trail-induced apoptosis in FADD-deficient mouse embryonic fibroblasts.". J. Biol. Chem. 275 (33): 25065–8. doi:. PMID 10862756.
- Miyazaki T, Reed JC (2001). "A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins.". Nat. Immunol. 2 (6): 493–500. doi:. PMID 11376335.
- Trauzold A, Wermann H, Arlt A, et al. (2001). "CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells.". Oncogene 20 (31): 4258–69. doi:. PMID 11464292.
- Dörr J, Bechmann I, Waiczies S, et al. (2002). "Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain.". J. Neurosci. 22 (4): RC209. PMID 11844843.
- Koyama S, Koike N, Adachi S (2002). "Expression of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in gastric carcinoma and tumor-infiltrating lymphocytes: a possible mechanism of immune evasion of the tumor.". J. Cancer Res. Clin. Oncol. 128 (2): 73–9. doi:. PMID 11862476.
- Guan B, Yue P, Lotan R, Sun SY (2002). "Evidence that the human death receptor 4 is regulated by activator protein 1.". Oncogene 21 (20): 3121–9. doi:. PMID 12082627.
- Söderström TS, Poukkula M, Holmström TH, et al. (2002). "Mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in activated T cells abrogates TRAIL-induced apoptosis upstream of the mitochondrial amplification loop and caspase-8.". J. Immunol. 169 (6): 2851–60. PMID 12218097.
|
|||||||||||
