TMPRSS6

From Wikipedia, the free encyclopedia

Transmembrane protease, serine 6

Identifiers

External IDs

OMIM: 609862 MGI: 1919003 HomoloGene: 12408

Gene ontology
Molecular Function:	• serine-type endopeptidase activity • peptidase activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• angiogenesis • proteolysis • intracellular signaling cascade • extracellular matrix organization and biogenesis • fibrinolysis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_153609 (mRNA)
NP_705837 (protein)

NM_027902 (mRNA)
NP_082178 (protein)

Location

Chr 22: 35.79 - 35.84 Mb

Chr 15: 78.27 - 78.3 Mb

Pubmed search

[1]

[2]

Transmembrane protease, serine 6, also known as TMPRSS6, is a human gene.^[1]

The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver.^[1]

[edit] References

^ ^a ^b Entrez Gene: TMPRSS6 transmembrane protease, serine 6.

[edit] Further reading

Netzel-Arnett S, Hooper JD, Szabo R, et al. (2004). "Membrane anchored serine proteases: a rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer.". Cancer Metastasis Rev. 22 (2-3): 237-58. PMID 12784999.
Ramsay AJ, Reid JC, Velasco G, et al. (2007). "The type II transmembrane serine protease matriptase-2--identification, structural features, enzymology, expression pattern and potential roles.". Front. Biosci. 13: 569-79. PMID 17981570.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489-95. doi:10.1038/990031. PMID 10591208.
Velasco G, Cal S, Quesada V, et al. (2002). "Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins.". J. Biol. Chem. 277 (40): 37637-46. doi:10.1074/jbc.M203007200. PMID 12149247.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Hartikainen JM, Tuhkanen H, Kataja V, et al. (2006). "Refinement of the 22q12-q13 breast cancer--associated region: evidence of TMPRSS6 as a candidate gene in an eastern Finnish population.". Clin. Cancer Res. 12 (5): 1454-62. doi:10.1158/1078-0432.CCR-05-1417. PMID 16533768.
Parr C, Sanders AJ, Davies G, et al. (2007). "Matriptase-2 inhibits breast tumor growth and invasion and correlates with favorable prognosis for breast cancer patients.". Clin. Cancer Res. 13 (12): 3568-76. doi:10.1158/1078-0432.CCR-06-2357. PMID 17575220.