TMPRSS2

From Wikipedia, the free encyclopedia

Transmembrane protease, serine 2

Identifiers

External IDs

OMIM: 602060 MGI: 1354381 HomoloGene: 4136

Gene ontology
Molecular Function:	• serine-type endopeptidase activity • scavenger receptor activity
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• proteolysis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005656 (mRNA)
NP_005647 (protein)

NM_015775 (mRNA)
NP_056590 (protein)

Location

Chr 21: 41.76 - 41.8 Mb

Chr 16: 97.72 - 97.75 Mb

Pubmed search

[1]

[2]

Transmembrane protease, serine 2, also known as TMPRSS2, is a human gene.^[1]

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. The biological function of this gene is unknown.^[1]

[edit] References

^ ^a ^b Entrez Gene: TMPRSS2 transmembrane protease, serine 2.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Paoloni-Giacobino A, Chen H, Peitsch MC, et al. (1997). "Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3.". Genomics 44 (3): 309–20. doi:10.1006/geno.1997.4845. PMID 9325052.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Lin B, Ferguson C, White JT, et al. (1999). "Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2.". Cancer Res. 59 (17): 4180–4. PMID 10485450.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
Vaarala MH, Porvari KS, Kellokumpu S, et al. (2001). "Expression of transmembrane serine protease TMPRSS2 in mouse and human tissues.". J. Pathol. 193 (1): 134–40. doi:10.1002/1096-9896(2000)9999:9999<::AID-PATH743>3.0.CO;2-T. PMID 11169526.
Afar DE, Vivanco I, Hubert RS, et al. (2001). "Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia.". Cancer Res. 61 (4): 1686–92. PMID 11245484.
Jacquinet E, Rao NV, Rao GV, et al. (2001). "Cloning and characterization of the cDNA and gene for human epitheliasin.". Eur. J. Biochem. 268 (9): 2687–99. PMID 11322890.
Teng DH, Chen Y, Lian L, et al. (2001). "Mutation analyses of 268 candidate genes in human tumor cell lines.". Genomics 74 (3): 352–64. doi:10.1006/geno.2001.6551. PMID 11414763.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wilson S, Greer B, Hooper J, et al. (2005). "The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells.". Biochem. J. 388 (Pt 3): 967–72. doi:10.1042/BJ20041066. PMID 15537383.
Soller MJ, Isaksson M, Elfving P, et al. (2006). "Confirmation of the high frequency of the TMPRSS2/ERG fusion gene in prostate cancer.". Genes Chromosomes Cancer 45 (7): 717–9. doi:10.1002/gcc.20329. PMID 16575875.
Tomlins SA, Mehra R, Rhodes DR, et al. (2006). "TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer.". Cancer Res. 66 (7): 3396–400. doi:10.1158/0008-5472.CAN-06-0168. PMID 16585160.
Yoshimoto M, Joshua AM, Chilton-Macneill S, et al. (2006). "Three-color FISH analysis of TMPRSS2/ERG fusions in prostate cancer indicates that genomic microdeletion of chromosome 21 is associated with rearrangement.". Neoplasia 8 (6): 465–9. doi:10.1593/neo.06283. PMID 16820092.
Böttcher E, Matrosovich T, Beyerle M, et al. (2006). "Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium.". J. Virol. 80 (19): 9896–8. doi:10.1128/JVI.01118-06. PMID 16973594.
Cerveira N, Ribeiro FR, Peixoto A, et al. (2006). "TMPRSS2-ERG gene fusion causing ERG overexpression precedes chromosome copy number changes in prostate carcinomas and paired HGPIN lesions.". Neoplasia 8 (10): 826–32. doi:10.1593/neo.06427. PMID 17032499.
Yoo NJ, Lee JW, Lee SH (2007). "Absence of fusion of TMPRSS2 and ETS transcription factor genes in gastric and colorectal carcinomas.". APMIS 115 (3): 252–3. doi:10.1111/j.1600-0463.2007.apm_652.x. PMID 17367471.
Winnes M, Lissbrant E, Damber JE, Stenman G (2007). "Molecular genetic analyses of the TMPRSS2-ERG and TMPRSS2-ETV1 gene fusions in 50 cases of prostate cancer.". Oncol. Rep. 17 (5): 1033–6. PMID 17390040.
Tu JJ, Rohan S, Kao J, et al. (2007). "Gene fusions between TMPRSS2 and ETS family genes in prostate cancer: frequency and transcript variant analysis by RT-PCR and FISH on paraffin-embedded tissues.". Mod. Pathol. 20 (9): 921–8. doi:10.1038/modpathol.3800903. PMID 17632455.