TMPRSS11D

From Wikipedia, the free encyclopedia

Transmembrane protease, serine 11D

Identifiers

TMPRSS11D; HAT; MGC150587; MGC150588

External IDs

OMIM: 605369 MGI: 2385221 HomoloGene: 74519

Gene ontology
Molecular Function:	• serine-type endopeptidase activity • peptidase activity
Cellular Component:	• extracellular region • integral to plasma membrane • membrane
Biological Process:	• proteolysis • respiratory gaseous exchange

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004262 (mRNA)
NP_004253 (protein)

XM_001001806 (mRNA)
XP_001001806 (protein)

Location

Chr 4: 68.37 - 68.43 Mb

Chr 5: 87.38 - 87.41 Mb

Pubmed search

[1]

[2]

Transmembrane protease, serine 11D, also known as TMPRSS11D, is a human gene.^[1]

This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions.^[1]

[edit] References

^ ^a ^b Entrez Gene: TMPRSS11D transmembrane protease, serine 11D.

[edit] Further reading

Yasuoka S, Ohnishi T, Kawano S, et al. (1997). "Purification, characterization, and localization of a novel trypsin-like protease found in the human airway.". Am. J. Respir. Cell Mol. Biol. 16 (3): 300-8. PMID 9070615.
Yamaoka K, Masuda K, Ogawa H, et al. (1998). "Cloning and characterization of the cDNA for human airway trypsin-like protease.". J. Biol. Chem. 273 (19): 11895-901. PMID 9565616.
Takahashi M, Sano T, Yamaoka K, et al. (2001). "Localization of human airway trypsin-like protease in the airway: an immunohistochemical study.". Histochem. Cell Biol. 115 (3): 181-7. PMID 11326745.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Miki M, Nakamura Y, Takahashi A, et al. (2003). "Effect of human airway trypsin-like protease on intracellular free Ca2+ concentration in human bronchial epithelial cells.". J. Med. Invest. 50 (1-2): 95-107. PMID 12630574.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Iwakiri K, Ghazizadeh M, Jin E, et al. (2004). "Human airway trypsin-like protease induces PAR-2-mediated IL-8 release in psoriasis vulgaris.". J. Invest. Dermatol. 122 (4): 937-44. doi:10.1111/j.0022-202X.2004.22415.x. PMID 15102084.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Matsushima R, Takahashi A, Nakaya Y, et al. (2006). "Human airway trypsin-like protease stimulates human bronchial fibroblast proliferation in a protease-activated receptor-2-dependent pathway.". Am. J. Physiol. Lung Cell Mol. Physiol. 290 (2): L385-95. doi:10.1152/ajplung.00098.2005. PMID 16199437.
Chokki M, Eguchi H, Hamamura I, et al. (2006). "Human airway trypsin-like protease induces amphiregulin release through a mechanism involving protease-activated receptor-2-mediated ERK activation and TNF alpha-converting enzyme activity in airway epithelial cells.". FEBS J. 272 (24): 6387-99. doi:10.1111/j.1742-4658.2005.05035.x. PMID 16336275.
Böttcher E, Matrosovich T, Beyerle M, et al. (2006). "Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium.". J. Virol. 80 (19): 9896-8. doi:10.1128/JVI.01118-06. PMID 16973594.