TMEM123

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Transmembrane protein 123
Identifiers
Symbol(s) TMEM123; PORMIN; KCT3; PORIMIN
External IDs OMIM: 606356 MGI: 1919179 HomoloGene: 14177
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 114908 71929
Ensembl ENSG00000152558 ENSMUSG00000050912
Uniprot Q8N131 Q91Z22
Refseq NM_052932 (mRNA)
NP_443164 (protein)		 XM_001005696 (mRNA)
XP_001005696 (protein)
Location Chr 11: 101.77 - 101.83 Mb Chr 9: 7.76 - 7.79 Mb
Pubmed search [1] [2]

Transmembrane protein 123, also known as TMEM123, is a human gene.[1]

This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death.[1]

[edit] References

  1. ^ a b Entrez Gene: TMEM123 transmembrane protein 123.

[edit] Further reading

  • Dekker J, Rossen JW, Büller HA, Einerhand AW (2002). "The MUC family: an obituary.". Trends Biochem. Sci. 27 (3): 126-31. PMID 11893509. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149. 
  • Zhang C, Xu Y, Gu J, Schlossman SF (1998). "A cell surface receptor defined by a mAb mediates a unique type of cell death similar to oncosis.". Proc. Natl. Acad. Sci. U.S.A. 95 (11): 6290-5. PMID 9600958. 
  • Ma F, Zhang C, Prasad KV, et al. (2001). "Molecular cloning of Porimin, a novel cell surface receptor mediating oncotic cell death.". Proc. Natl. Acad. Sci. U.S.A. 98 (17): 9778-83. doi:10.1073/pnas.171322898. PMID 11481458. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Bonkobara M, Das A, Takao J, et al. (2003). "Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes.". Br. J. Dermatol. 148 (4): 654-64. PMID 12752121. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819-24. doi:10.1110/ps.04682504. PMID 15340161. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117-26. doi:10.1093/dnares/12.2.117. PMID 16303743. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560. 
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