TMED1

From Wikipedia, the free encyclopedia

Transmembrane emp24 protein transport domain containing 1

Identifiers

TMED1; ST2L; IL1RL1LG; Il1rl1l; MGC1270

External IDs

OMIM: 605395 MGI: 106201 HomoloGene: 21360

Gene ontology
Molecular Function:	• receptor binding
Cellular Component:	• membrane • integral to membrane
Biological Process:	• transport • signal transduction • cell-cell signaling

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006858 (mRNA)
NP_006849 (protein)

NM_010744 (mRNA)
NP_034874 (protein)

Location

Chr 19: 10.8 - 10.81 Mb

Chr 9: 21.26 - 21.26 Mb

Pubmed search

[1]

[2]

Transmembrane emp24 protein transport domain containing 1, also known as TMED1, is a human gene.^[1]

The protein encoded by this gene was identified by its interaction with interleukin 1 receptor-like 1 (IL1RL1). This protein lacks any similarity to other interleukin 1 ligands. The functional significance of its interaction with IL1RL1 is not known.^[1]

[edit] References

^ ^a ^b Entrez Gene: TMED1 transmembrane emp24 protein transport domain containing 1.

[edit] Further reading

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324-32. doi:10.1101/gr.2334104. PMID 15231748.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529-35. doi:10.1038/nature02399. PMID 15057824.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Chan WL, Pejnovic N, Lee CA, Al-Ali NA (2001). "Human IL-18 receptor and ST2L are stable and selective markers for the respective type 1 and type 2 circulating lymphocytes.". J. Immunol. 167 (3): 1238-44. PMID 11466339.
Gayle MA, Slack JL, Bonnert TP, et al. (1996). "Cloning of a putative ligand for the T1/ST2 receptor.". J. Biol. Chem. 271 (10): 5784-9. PMID 8621446.