TM7SF2

From Wikipedia, the free encyclopedia

Transmembrane 7 superfamily member 2

Identifiers

TM7SF2; ANG1; DHCR14A

External IDs

OMIM: 603414 MGI: 1920416 HomoloGene: 68305

Gene ontology
Molecular Function:	• oxidoreductase activity • delta14-sterol reductase activity
Cellular Component:	• endoplasmic reticulum • integral to plasma membrane • membrane
Biological Process:	• cholesterol biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_003273 (mRNA)
NP_003264 (protein)

NM_028454 (mRNA)
NP_082730 (protein)

Location

Chr 11: 64.64 - 64.64 Mb

Chr 19: 6.06 - 6.07 Mb

Pubmed search

[1]

[2]

Transmembrane 7 superfamily member 2, also known as TM7SF2, is a human gene.^[1]

[edit] References

^ Entrez Gene: TM7SF2 transmembrane 7 superfamily member 2.

[edit] Further reading

Bennati AM, Castelli M, Della Fazia MA, et al. (2006). "Sterol dependent regulation of human TM7SF2 gene expression: role of the encoded 3beta-hydroxysterol Delta14-reductase in human cholesterol biosynthesis.". Biochim. Biophys. Acta 1761 (7): 677-85. doi:10.1016/j.bbalip.2006.05.004. PMID 16784888.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Prakash A, Kasbekar DP (2002). "Genes encoding chimeras of Neurospora crassa erg-3 and human TM7SF2 proteins fail to complement Neurospora and yeast sterol C-14 reductase mutants.". J. Biosci. 27 (2): 105-12. PMID 11937680.
Roberti R, Bennati AM, Galli G, et al. (2002). "Cloning and expression of sterol Delta 14-reductase from bovine liver.". Eur. J. Biochem. 269 (1): 283-90. PMID 11784322.
Holmer L, Pezhman A, Worman HJ (1999). "The human lamin B receptor/sterol reductase multigene family.". Genomics 54 (3): 469-76. doi:10.1006/geno.1998.5615. PMID 9878250.
Lemmens IH, Kas K, Merregaert J, Van de Ven WJ (1998). "Identification and molecular characterization of TM7SF2 in the FAUNA gene cluster on human chromosome 11q13.". Genomics 49 (3): 437-42. doi:10.1006/geno.1998.5296. PMID 9615229.
Lemmens I, Merregaert J, Van de Ven WJ, et al. (1997). "Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1.". Genomics 44 (1): 94-100. PMID 9286704.