TM4SF5

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Transmembrane 4 L six family member 5
Identifiers
Symbol(s) TM4SF5;
External IDs OMIM: 604657 MGI: 1922854 HomoloGene: 2947
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9032 75604
Ensembl ENSG00000142484 ENSMUSG00000018919
Uniprot O14894 n/a
Refseq NM_003963 (mRNA)
NP_003954 (protein)		 NM_029360 (mRNA)
NP_083636 (protein)
Location Chr 17: 4.62 - 4.63 Mb Chr 11: 70.32 - 70.33 Mb
Pubmed search [1] [2]

Transmembrane 4 L six family member 5, also known as TM4SF5, is a human gene.[1]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells.[1]

[edit] References

  1. ^ a b Entrez Gene: TM4SF5 transmembrane 4 L six family member 5.

[edit] Further reading

  • Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye.". J. Cell. Sci. 114 (Pt 23): 4143-51. PMID 11739647. 
  • Lee SY, Kim YT, Lee MS, et al. (2006). "Focal adhesion and actin organization by a cross-talk of TM4SF5 with integrin alpha2 are regulated by serum treatment.". Exp. Cell Res. 312 (16): 2983-99. doi:10.1016/j.yexcr.2006.06.001. PMID 16828471. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Kaneko R, Tsuji N, Kamagata C, et al. (2002). "Amount of expression of the tumor-associated antigen L6 gene and transmembrane 4 superfamily member 5 gene in gastric cancers and gastric mucosa.". Am. J. Gastroenterol. 96 (12): 3457-8. PMID 11774983. 
  • Wright MD, Ni J, Rudy GB (2000). "The L6 membrane proteins--a new four-transmembrane superfamily.". Protein Sci. 9 (8): 1594-600. PMID 10975581. 
  • Müller-Pillasch F, Wallrapp C, Lacher U, et al. (1998). "Identification of a new tumour-associated antigen TM4SF5 and its expression in human cancer.". Gene 208 (1): 25-30. PMID 9479038. 
  • Gress TM, Müller-Pillasch F, Geng M, et al. (1996). "A pancreatic cancer-specific expression profile.". Oncogene 13 (8): 1819-30. PMID 8895530. 
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