TLX3

From Wikipedia, the free encyclopedia

T-cell leukemia homeobox 3

Identifiers

TLX3; HOX11L2; MGC29804; RNX

External IDs

OMIM: 604640 MGI: 1351209 HomoloGene: 23181

Gene ontology
Molecular Function:	• transcription factor activity • protein binding • sequence-specific DNA binding
Cellular Component:	• nucleus
Biological Process:	• neuron migration • regulation of transcription, DNA-dependent • multicellular organismal development • central nervous system development • respiratory gaseous exchange • neuron differentiation • negative regulation of neuron differentiation • neuron fate specification

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_021025 (mRNA)
NP_066305 (protein)

NM_019916 (mRNA)
NP_064300 (protein)

Location

Chr 5: 170.67 - 170.67 Mb

Chr 11: 33.1 - 33.1 Mb

Pubmed search

[1]

[2]

T-cell leukemia homeobox 3, also known as TLX3, is a human gene.^[1]

RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription factors. Members of the HOX11 gene family are characterized by a threonine-47 replacing cytosine in the highly conserved homeodomain (Dear et al., 1993).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: TLX3 T-cell leukemia homeobox 3.

[edit] Further reading

Dear TN, Sanchez-Garcia I, Rabbitts TH (1993). "The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes.". Proc. Natl. Acad. Sci. U.S.A. 90 (10): 4431-5. PMID 8099440.
Cinti R, Fava M, Sancandi M, et al. (2001). "Assignment of the HOX11L2 gene to human chromosome band 5q35.1 and of its murine homolog to mouse chromosome bands 11A4-A5 by in situ hybridization.". Cytogenet. Cell Genet. 92 (3-4): 354-5. PMID 11435716.
Lee-Kirsch MA, Engel K, Paditz E, et al. (2001). "Assignment of the human homeobox 11-like 2 gene (HOX11L2) to chromosome 5q34-->q35 by radiation hybrid mapping.". Cytogenet. Cell Genet. 92 (3-4): 358. PMID 11435718.
Bernard OA, Busson-LeConiat M, Ballerini P, et al. (2002). "A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia.". Leukemia 15 (10): 1495-504. PMID 11587205.
Ballerini P, Blaise A, Busson-Le Coniat M, et al. (2002). "HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosis.". Blood 100 (3): 991-7. doi:10.1182/blood-2001-11-0093. PMID 12130513.
Matera I, Bachetti T, Cinti R, et al. (2003). "Mutational analysis of the RNX gene in congenital central hypoventilation syndrome.". Am. J. Med. Genet. 113 (2): 178-82. doi:10.1002/ajmg.10746. PMID 12407709.
Mauvieux L, Leymarie V, Helias C, et al. (2003). "High incidence of Hox11L2 expression in children with T-ALL.". Leukemia 16 (12): 2417-22. doi:10.1038/sj.leu.2402709. PMID 12454747.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Berger R, Dastugue N, Busson M, et al. (2003). "t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Groupe Français de Cytogénétique Hématologique (GFCH).". Leukemia 17 (9): 1851-7. doi:10.1038/sj.leu.2403061. PMID 12970786.
Cavé H, Suciu S, Preudhomme C, et al. (2004). "Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951.". Blood 103 (2): 442-50. doi:10.1182/blood-2003-05-1495. PMID 14504110.
Su XY, Busson M, Della Valle V, et al. (2004). "Various types of rearrangements target TLX3 locus in T-cell acute lymphoblastic leukemia.". Genes Chromosomes Cancer 41 (3): 243-9. doi:10.1002/gcc.20088. PMID 15334547.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ballerini P, Busson M, Fasola S, et al. (2005). "NUP214-ABL1 amplification in t(5;14)/HOX11L2-positive ALL present with several forms and may have a prognostic significance.". Leukemia 19 (3): 468-70. doi:10.1038/sj.leu.2403654. PMID 15674415.
Gottardo NG, Jacoby PA, Sather HN, et al. (2005). "Significance of HOX11L2/TLX3 expression in children with T-cell acute lymphoblastic leukemia treated on Children's Cancer Group protocols.". Leukemia 19 (9): 1705-8. doi:10.1038/sj.leu.2403834. PMID 15990867.
Borghini S, Vargiolu M, Di Duca M, et al. (2006). "Nuclear factor Y drives basal transcription of the human TLX3, a gene overexpressed in T-cell acute lymphocytic leukemia.". Mol. Cancer Res. 4 (9): 635-43. doi:10.1158/1541-7786.MCR-05-0250. PMID 16966433.
Nagel S, Scherr M, Kel A, et al. (2007). "Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1.". Cancer Res. 67 (4): 1461-71. doi:10.1158/0008-5472.CAN-06-2615. PMID 17308084.