TLX2

From Wikipedia, the free encyclopedia

T-cell leukemia homeobox 2

Identifiers

TLX2; Enx; HOX11L1; NCX

External IDs

OMIM: 604240 MGI: 1350935 HomoloGene: 7575

Gene ontology
Molecular Function:	• molecular_function • transcription factor activity • protein binding • sequence-specific DNA binding
Cellular Component:	• cellular_component • nucleus • cytoplasm
Biological Process:	• regulation of transcription, DNA-dependent • multicellular organismal development • biological_process • negative regulation of dendrite morphogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016170 (mRNA)
NP_057254 (protein)

NM_009392 (mRNA)
NP_033418 (protein)

Location

Chr 2: 74.59 - 74.6 Mb

Chr 6: 83.03 - 83.04 Mb

Pubmed search

[1]

[2]

T-cell leukemia homeobox 2, also known as TLX2, is a human gene.^[1]

[edit] References

^ Entrez Gene: TLX2 T-cell leukemia homeobox 2.

[edit] Further reading

Kaifi JT, Wagner M, Schurr PG, et al. (2007). "Allelic loss of Hox11L1 gene locus predicts outcome of gastrointestinal stromal tumors.". Oncol. Rep. 16 (4): 915–9. PMID 16969514.
Borghini S, Bachetti T, Fava M, et al. (2006). "The TLX2 homeobox gene is a transcriptional target of PHOX2B in neural-crest-derived cells.". Biochem. J. 395 (2): 355–61. doi:10.1042/BJ20051386. PMID 16402914.
Parisi MA, Lipman NS, Clarke CM, et al. (2006). "Evaluation of Hox11L1 in the fmc/fmc rat model of chronic intestinal pseudo-obstruction.". J. Pediatr. Surg. 40 (11): 1760–5. doi:10.1016/j.jpedsurg.2005.07.010. PMID 16291166.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Iitsuka Y, Shimizu H, Kang MM, et al. (1999). "An enhancer element for expression of the Ncx (Enx, Hox11L1) gene in neural crest-derived cells.". J. Biol. Chem. 274 (34): 24401–7. PMID 10446220.
Puliti A, Cinti R, Betsos N, et al. (1999). "HOX11L1, a gene involved in peripheral nervous system development, maps to human chromosome 2p13.1-->p12 and mouse chromosome 6C3-D1.". Cytogenet. Cell Genet. 84 (1-2): 115–7. PMID 10343123.
Tang SJ, Suen TC, McInnes RR, Buchwald M (1998). "Association of the TLX-2 homeodomain and 14-3-3eta signaling proteins.". J. Biol. Chem. 273 (39): 25356–63. PMID 9738002.