TLR 7

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Toll-like receptor 7
Identifiers
Symbol(s)	TLR7;
External IDs	OMIM: 300365 MGI: 2176882 HomoloGene: 75060
Gene ontology Molecular Function: • double-stranded RNA binding • single-stranded RNA binding • transmembrane receptor activity • protein binding • siRNA binding Cellular Component: • membrane • integral to membrane Biological Process: • inflammatory response • immune response • positive regulation of interferon-gamma biosynthetic process • positive regulation of interferon-alpha biosynthetic process • positive regulation of interferon-beta biosynthetic process • positive regulation of interleukin-8 biosynthetic process • defense response to virus
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	51284	170743
Ensembl	ENSG00000196664	ENSMUSG00000044583
Uniprot	Q9NYK1	Q3T997
Refseq	NM_016562 (mRNA) NP_057646 (protein)	XM_989349 (mRNA) XP_994443 (protein)
Location	Chr X: 12.8 - 12.82 Mb	Chr X: 162.65 - 162.67 Mb
Pubmed search	[1]	[2]

Toll-like receptor 7, also known as TLR7, is an immune gene possessed by humans and other mammals and additionally in avian species.

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different pattern of expressionpatterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on human chromosome X.^[1] Imiquimod acts upon TLR 7.^[2]

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• MeSH Toll-Like+Receptor+7

v • d • e Transmembrane receptors: immune receptors Cytokine receptor Type I: Interleukins (2, 3, 4, 5, 6, 7, 9, 11, 12, 13, 15, 21, 23, 27), CSF receptors (EPO, GM-CSF, G-CSF), GH, prolactin, Oncostatin M,Leukemia inhibitory factor - common subunits (Common gamma chain, common beta chain, CSF2RB) Type II: Interleukins (10, 20, 22, 28) - interferon (-α/β, -γ) immunoglobulin superfamily: CSF1, C-kit, IL-1, IL-18 Tumor necrosis factor: CD27, CD30, CD40, CD120, Lymphotoxin β Chemokines: IL-8 (α, β), CCR1,CXCR4 Other: IL-17, TGF-beta (1, 2) Pattern recognition/Toll-like TLR 1 - TLR 2 - TLR 3 - TLR 4 - TLR 5 - TLR 6 - TLR 7 - TLR 8 - TLR 9 - TLR 10 Fc receptor ε (FcεRI, FcεRII) - γ (FcγRI, FcγRII, FcγRIII) - α/μ (FcαRI, Fcα/μR) - Neonatal Lymphocyte homing receptor CD44 - L-selectin - VLA-4 - LFA-1 other Antigen receptor (B-cell, T cell) - Complement - Formyl peptide - Immunophilins - Integrin - Killer-cell immunoglobulin-like - Scavenger