TLR 5

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Toll-like receptor 5
Identifiers
Symbol(s)	TLR5; FLJ10052; MGC126430; MGC126431; SLEB1; TIL3
External IDs	OMIM: 603031 HomoloGene: 20698
Gene ontology Molecular Function: • receptor activity • transmembrane receptor activity • protein binding Cellular Component: • membrane • integral to membrane Biological Process: • inflammatory response • innate immune response
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	7100	n/a
Ensembl	ENSG00000187554	n/a
Uniprot	O60602	n/a
Refseq	NM_003268 (mRNA) NP_003259 (protein)	n/a (mRNA) n/a (protein)
Location	Chr 1: 221.35 - 221.38 Mb	n/a
Pubmed search	[1]	n/a

Toll-like receptor 5, also known as TLR5, is a human gene.

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene product is expressed in myelomonocytic cells, and recognizes bacterial flagellin, a principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB and stimulates tumour necrosis factor-alpha production.^[1]

TLR5 recognizes flagellin.^[2] Flagellin is the protein monomer that makes up the filament of bacterial flagella, found on nearly all motile bacteria. There are highly conserved regions in the flagellin protein among all bacteria, facilitating the recognition of flagellin by a germ-line encoded receptor such as TLR5.^[3]

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• MeSH Toll-Like+Receptor+5

v • d • e Transmembrane receptors: immune receptors Cytokine receptor Type I: Interleukins (2, 3, 4, 5, 6, 7, 9, 11, 12, 13, 15, 21, 23, 27), CSF receptors (EPO, GM-CSF, G-CSF), GH, prolactin, Oncostatin M,Leukemia inhibitory factor - common subunits (Common gamma chain, common beta chain, CSF2RB) Type II: Interleukins (10, 20, 22, 28) - interferon (-α/β, -γ) immunoglobulin superfamily: CSF1, C-kit, IL-1, IL-18 Tumor necrosis factor: CD27, CD30, CD40, CD120, Lymphotoxin β Chemokines: IL-8 (α, β), CCR1,CXCR4 Other: IL-17, TGF-beta (1, 2) Pattern recognition/Toll-like TLR 1 - TLR 2 - TLR 3 - TLR 4 - TLR 5 - TLR 6 - TLR 7 - TLR 8 - TLR 9 - TLR 10 Fc receptor ε (FcεRI, FcεRII) - γ (FcγRI, FcγRII, FcγRIII) - α/μ (FcαRI, Fcα/μR) - Neonatal Lymphocyte homing receptor CD44 - L-selectin - VLA-4 - LFA-1 other Antigen receptor (B-cell, T cell) - Complement - Formyl peptide - Immunophilins - Integrin - Killer-cell immunoglobulin-like - Scavenger