TLR6
From Wikipedia, the free encyclopedia
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Toll-like receptor 6
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| Identifiers | ||
| Symbol(s) | TLR6; CD286 | |
| External IDs | OMIM: 605403 MGI: 1341296 HomoloGene: 21223 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 10333 | 21899 |
| Ensembl | ENSG00000174130 | ENSMUSG00000051498 |
| Uniprot | Q9Y2C9 | Q0PM14 |
| Refseq | NM_006068 (mRNA) NP_006059 (protein) |
NM_011604 (mRNA) NP_035734 (protein) |
| Location | Chr 4: 38.5 - 38.51 Mb | Chr 5: 65.23 - 65.24 Mb |
| Pubmed search | [1] | [2] |
Toll-like receptor 6, also known as TLR6, is a human gene. TLR6 has also been designated as CD286 (cluster of differentiation 286).
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins.[1]
[edit] References
[edit] Further reading
- Lien E, Ingalls RR (2002). "Toll-like receptors.". Crit. Care Med. 30 (1 Suppl): S1-11. PMID 11782555.
[edit] External links
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