TLR10

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Toll-like receptor 10
PDB rendering based on 2j67.
Available structures: 2j67
Identifiers
Symbol(s)	TLR10; MGC104967; MGC126398; MGC126399; CD290
External IDs	OMIM: 606270 HomoloGene: 12809
Gene ontology Molecular Function: • transmembrane receptor activity • protein binding Cellular Component: • membrane • integral to membrane Biological Process: • inflammatory response • innate immune response
Orthologs
	Human	Mouse
Entrez	81793	n/a
Ensembl	ENSG00000174123	n/a
Uniprot	Q9BXR5	n/a
Refseq	NM_001017388 (mRNA) NP_001017388 (protein)	n/a (mRNA) n/a (protein)
Location	Chr 4: 38.45 - 38.46 Mb	n/a
Pubmed search	[1]	n/a

Toll-like receptor 10, also known as TLR10, is a human gene. TLR10 has also been designated as CD290 (cluster of differentiation 290).

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Its exact function is not known. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.^[1]

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[edit] Further reading

[edit] External links

• MeSH Toll-Like+Receptor+10

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