TLN1

From Wikipedia, the free encyclopedia

Talin 1

PDB rendering based on 1mix.

Available structures: 1mix, 1miz, 1mk7, 1mk9, 1sj7, 1sj8, 1u89, 1y19, 2b0h, 2g35, 2h7d, 2h7e

Identifiers

Symbol(s)

TLN1; ILWEQ; TLN; KIAA1027

External IDs

OMIM: 186745 MGI: 1099832 HomoloGene: 21267

Gene ontology
Molecular Function:	• actin binding • structural constituent of cytoskeleton • binding • protein binding • vinculin binding • LIM domain binding
Cellular Component:	• ruffle • cytosol • cytoskeleton • intercellular junction • focal adhesion
Biological Process:	• cell motility • cytoskeletal anchoring • intercellular junction assembly

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006289 (mRNA)
NP_006280 (protein)

NM_011602 (mRNA)
NP_035732 (protein)

Location

Chr 9: 35.69 - 35.72 Mb

Chr 4: 43.55 - 43.58 Mb

Pubmed search

[1]

[2]

Talin 1, also known as TLN1, is a human gene.

This gene encodes a cytoskeletal protein which is concentrated in areas of cell-substratum and cell-cell contacts. This protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin.^[1]

[edit] See also

Talin protein

[edit] References

^ Entrez Gene: TLN1 talin 1.

[edit] Further reading

Luna EJ, Hitt AL (1992). "Cytoskeleton--plasma membrane interactions.". Science 258 (5084): 955–64. PMID 1439807.
Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. PMID 12168954.
Critchley DR (2005). "Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion.". Biochem. Soc. Trans. 32 (Pt 5): 831–6. doi:10.1042/BST0320831. PMID 15494027.