TLL2

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Tolloid-like 2
Identifiers
Symbol(s) TLL2; KIAA0932; MGC133312; MGC133313
External IDs OMIM: 606743 MGI: 1346044 HomoloGene: 56545
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 7093 24087
Ensembl ENSG00000095587 ENSMUSG00000025013
Uniprot Q9Y6L7 Q9WVM6
Refseq NM_012465 (mRNA)
NP_036597 (protein)		 NM_011904 (mRNA)
NP_036034 (protein)
Location Chr 10: 98.11 - 98.26 Mb Chr 19: 41.14 - 41.26 Mb
Pubmed search [1] [2]

Tolloid-like 2, also known as TLL2, is a human gene.[1]

This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or chordin.[1]

[edit] References

  1. ^ a b Entrez Gene: TLL2 tolloid-like 2.

[edit] Further reading

  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (1): 63-70. PMID 10231032. 
  • Scott IC, Blitz IL, Pappano WN, et al. (1999). "Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis.". Dev. Biol. 213 (2): 283-300. doi:10.1006/dbio.1999.9383. PMID 10479448. 
  • Scott IC, Clark TG, Takahara K, et al. (1999). "Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32-->q33 and 10q23-->q24 and assignment of murine Tll2 to chromosome 19.". Cytogenet. Cell Genet. 86 (1): 64-5. PMID 10516436. 
  • Reynolds SD, Zhang D, Puzas JE, et al. (2000). "Cloning of the chick BMP1/Tolloid cDNA and expression in skeletal tissues.". Gene 248 (1-2): 233-43. PMID 10806368. 
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863. 
  • Uzel MI, Scott IC, Babakhanlou-Chase H, et al. (2001). "Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures.". J. Biol. Chem. 276 (25): 22537-43. doi:10.1074/jbc.M102352200. PMID 11313359. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375-81. doi:10.1038/nature02462. PMID 15164054. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
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