TLK1

From Wikipedia, the free encyclopedia

Tousled-like kinase 1

Identifiers

TLK1; KIAA0137; PKU-BETA

External IDs

OMIM: 608438 MGI: 2441683 HomoloGene: 8185

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • ATP binding • transferase activity
Cellular Component:	• cellular_component • nucleus
Biological Process:	• regulation of chromatin assembly or disassembly • protein amino acid phosphorylation • intracellular protein transport • response to DNA damage stimulus • cell cycle • intracellular signaling cascade • chromatin modification

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012290 (mRNA)
NP_036422 (protein)

XM_001002185 (mRNA)
XP_001002185 (protein)

Location

Chr 2: 171.56 - 171.73 Mb

Chr 2: 70.51 - 70.63 Mb

Pubmed search

[1]

[2]

Tousled-like kinase 1, also known as TLK1, is a human gene.^[1]

The Tousled-like kinases, first described in Arabadopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: TLK1 tousled-like kinase 1.

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. PMID 12168954.
Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans.". Cell Growth Differ. 4 (10): 821–30. PMID 8274451.
Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 2 (4): 167–74, 199–210. PMID 8590280.
Yamakawa A, Kameoka Y, Hashimoto K, et al. (1998). "cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal.". Gene 202 (1-2): 193–201. PMID 9427565.
Silljé HH, Takahashi K, Tanaka K, et al. (1999). "Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication.". EMBO J. 18 (20): 5691–702. doi:10.1093/emboj/18.20.5691. PMID 10523312.
Cabaniols JP, Ravichandran V, Roche PA (2000). "Phosphorylation of SNAP-23 by the novel kinase SNAK regulates t-SNARE complex assembly.". Mol. Biol. Cell 10 (12): 4033–41. PMID 10588641.
Li Y, DeFatta R, Anthony C, et al. (2001). "A translationally regulated Tousled kinase phosphorylates histone H3 and confers radioresistance when overexpressed.". Oncogene 20 (6): 726–38. doi:10.1038/sj.onc.1204147. PMID 11314006.
Silljé HH, Nigg EA (2001). "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases.". Curr. Biol. 11 (13): 1068–73. PMID 11470414.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Groth A, Lukas J, Nigg EA, et al. (2003). "Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint.". EMBO J. 22 (7): 1676–87. doi:10.1093/emboj/cdg151. PMID 12660173.
Krause DR, Jonnalagadda JC, Gatei MH, et al. (2003). "Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1.". Oncogene 22 (38): 5927–37. doi:10.1038/sj.onc.1206691. PMID 12955071.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Norton KS, McClusky D, Sen S, et al. (2004). "TLK1B is elevated with eIF4E overexpression in breast cancer.". J. Surg. Res. 116 (1): 98–103. PMID 14732354.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Kodym R, Henöckl C, Fürweger C (2005). "Identification of the human DEAD-box protein p68 as a substrate of Tlk1.". Biochem. Biophys. Res. Commun. 333 (2): 411–7. doi:10.1016/j.bbrc.2005.05.136. PMID 15950181.
Sunavala-Dossabhoy G, Balakrishnan SK, Sen S, et al. (2006). "The radioresistance kinase TLK1B protects the cells by promoting repair of double strand breaks.". BMC Mol. Biol. 6: 19. doi:10.1186/1471-2199-6-19. PMID 16156902.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Sen SP, De Benedetti A (2006). "TLK1B promotes repair of UV-damaged DNA through chromatin remodeling by Asf1.". BMC Mol. Biol. 7: 37. doi:10.1186/1471-2199-7-37. PMID 17054786.