TLE4

From Wikipedia, the free encyclopedia

Transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)

PDB rendering based on 1gxr.

Available structures: 1gxr, 2ce8, 2ce9

Identifiers

Symbol(s)

TLE4; ESG; BCE-1; E(spI); ESG4; GRG4

External IDs

OMIM: 605132 MGI: 104633 HomoloGene: 38259

Gene ontology
Molecular Function:	• molecular_function
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • Wnt receptor signaling pathway • biological_process • regulation of transcription

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007005 (mRNA)
NP_008936 (protein)

XM_001000013 (mRNA)
XP_001000013 (protein)

Location

Chr 9: 81.38 - 81.53 Mb

Chr 19: 14.52 - 14.67 Mb

Pubmed search

[1]

[2]

Transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila), also known as TLE4, is a human gene.^[1]

[edit] References

^ Entrez Gene: TLE4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila).

[edit] Further reading

Stifani S, Blaumueller CM, Redhead NJ, et al. (1993). "Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins.". Nat. Genet. 2 (2): 119-27. doi:10.1038/ng1092-119. PMID 1303260.
Miyasaka H, Choudhury BK, Hou EW, Li SS (1993). "Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein.". Eur. J. Biochem. 216 (1): 343-52. PMID 8365415.
Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (5): 337-45. PMID 10574462.
Eberhard D, Jiménez G, Heavey B, Busslinger M (2000). "Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family.". EMBO J. 19 (10): 2292-303. doi:10.1093/emboj/19.10.2292. PMID 10811620.
Milili M, Gauthier L, Veran J, et al. (2002). "A new Groucho TLE4 protein may regulate the repressive activity of Pax5 in human B lymphocytes.". Immunology 106 (4): 447-55. PMID 12153506.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369-74. doi:10.1038/nature02465. PMID 15164053.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Heimbucher T, Murko C, Bajoghli B, et al. (2007). "Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors.". Mol. Cell. Biol. 27 (1): 340-51. doi:10.1128/MCB.00811-06. PMID 17060451.