TLE2

From Wikipedia, the free encyclopedia

Transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)

Identifiers

TLE2; ESG; ESG2; FLJ41188; GRG2

External IDs

OMIM: 601041 MGI: 104635 HomoloGene: 20693

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • signal transduction • Wnt receptor signaling pathway • organ morphogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003260 (mRNA)
NP_003251 (protein)

NM_019725 (mRNA)
NP_062699 (protein)

Location

Chr 19: 2.95 - 2.98 Mb

Chr 10: 80.98 - 80.99 Mb

Pubmed search

[1]

[2]

Transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila), also known as TLE2, is a human gene.^[1]

[edit] References

^ Entrez Gene: TLE2 transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila).

[edit] Further reading

Stifani S, Blaumueller CM, Redhead NJ, et al. (1993). "Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins.". Nat. Genet. 2 (2): 119–27. doi:10.1038/ng1092-119. PMID 1303260.
Miyasaka H, Choudhury BK, Hou EW, Li SS (1993). "Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein.". Eur. J. Biochem. 216 (1): 343–52. PMID 8365415.
Liu Y, Dehni G, Purcell KJ, et al. (1996). "Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia.". Genomics 31 (1): 58–64. doi:10.1006/geno.1996.0009. PMID 8808280.
Palaparti A, Baratz A, Stifani S (1997). "The Groucho/transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of histone H3.". J. Biol. Chem. 272 (42): 26604–10. PMID 9334241.
Grbavec D, Lo R, Liu Y, et al. (1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms.". Biochem. J. 337 ( Pt 1): 13–7. PMID 9854018.
Grbavec D, Lo R, Liu Y, Stifani S (1999). "Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development.". Eur. J. Biochem. 258 (2): 339–49. PMID 9874198.
Ren B, Chee KJ, Kim TH, Maniatis T (1999). "PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins.". Genes Dev. 13 (1): 125–37. PMID 9887105.
Javed A, Guo B, Hiebert S, et al. (2000). "Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBF(alpha)/AML/PEBP2(alpha)) dependent activation of tissue-specific gene transcription.". J. Cell. Sci. 113 ( Pt 12): 2221–31. PMID 10825294.
Brantjes H, Roose J, van De Wetering M, Clevers H (2001). "All Tcf HMG box transcription factors interact with Groucho-related co-repressors.". Nucleic Acids Res. 29 (7): 1410–9. PMID 11266540.
Dintilhac A, Bernués J (2002). "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences.". J. Biol. Chem. 277 (9): 7021–8. doi:10.1074/jbc.M108417200. PMID 11748221.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Higa LA, Wu M, Ye T, et al. (2006). "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.". Nat. Cell Biol. 8 (11): 1277–83. doi:10.1038/ncb1490. PMID 17041588.