TIP39

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Tuberoinfundibular 39 residue protein precursor
Identifiers
Symbol(s) TIP39;
External IDs OMIM: 608386 MGI: 2152297 HomoloGene: 14235
Orthologs
Human Mouse
Entrez 113091 114640
Ensembl ENSG00000142538 ENSMUSG00000038300
Uniprot Q96A98 Q91W27
Refseq NM_178449 (mRNA)
NP_848544 (protein)		 NM_053256 (mRNA)
NP_444486 (protein)
Location Chr 19: 54.62 - 54.62 Mb Chr 7: 45.05 - 45.05 Mb
Pubmed search [1] [2]

Tuberoinfundibular 39 residue protein precursor, also known as TIP39, is a human gene.[1]

TIP39 is related to parathyroid hormone (PTH; MIM 168450) and PTH-related protein (PTHRP; MIM 168470) and is a ligand for PTH receptor-2 (PTHR2; MIM 601469) (John et al., 2002).[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: TIP39 tuberoinfundibular 39 residue protein precursor.

[edit] Further reading

  • Usdin TB, Hoare SR, Wang T, et al. (1999). "TIP39: a new neuropeptide and PTH2-receptor agonist from hypothalamus.". Nat. Neurosci. 2 (11): 941–3. doi:10.1038/14724. PMID 10526330. 
  • Hoare SR, Clark JA, Usdin TB (2000). "Molecular determinants of tuberoinfundibular peptide of 39 residues (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor binding selectivity.". J. Biol. Chem. 275 (35): 27274–83. doi:10.1074/jbc.M003910200. PMID 10854439. 
  • Dobolyi A, Ueda H, Uchida H, et al. (2002). "Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception.". Proc. Natl. Acad. Sci. U.S.A. 99 (3): 1651–6. doi:10.1073/pnas.042416199. PMID 11818570. 
  • John MR, Arai M, Rubin DA, et al. (2002). "Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues.". Endocrinology 143 (3): 1047–57. PMID 11861531. 
  • Hansen IA, Jakob O, Wortmann S, et al. (2002). "Characterization of the human and mouse genes encoding the tuberoinfundibular peptide of 39 residues, a ligand of the parathyroid hormone receptor family.". J. Endocrinol. 174 (1): 95–102. PMID 12098667. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Della Penna K, Kinose F, Sun H, et al. (2003). "Tuberoinfundibular peptide of 39 residues (TIP39): molecular structure and activity for parathyroid hormone 2 receptor.". Neuropharmacology 44 (1): 141–53. PMID 12559132. 
  • Misiano P, Scott BB, Scheideler MA, Garnier M (2004). "PTH2 receptor-mediated inhibitory effect of parathyroid hormone and TIP39 on cell proliferation.". Eur. J. Pharmacol. 468 (3): 159–66. PMID 12754053. 
  • Bisello A, Manen D, Pierroz DD, et al. (2004). "Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization.". Mol. Endocrinol. 18 (6): 1486–98. doi:10.1210/me.2003-0487. PMID 14988434. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
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