TIMP2

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TIMP metallopeptidase inhibitor 2
PDB rendering based on 1bqq.
Available structures: 1bqq, 1br9, 1buv, 1gxd, 2e2d, 2tmp
Identifiers
Symbol(s)	TIMP2; CSC-21K
External IDs	OMIM: 188825 MGI: 98753 HomoloGene: 2444
Gene ontology Molecular Function: • enzyme inhibitor activity • integrin binding • enzyme activator activity • metalloendopeptidase inhibitor activity Cellular Component: • proteinaceous extracellular matrix • basement membrane • cell surface Biological Process: • metabolic process • negative regulation of cell proliferation • regulation of cAMP metabolic process • regulation of MAPKKK cascade • regulation of neuron differentiation
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	7077	21858
Ensembl	ENSG00000035862	ENSMUSG00000017466
Uniprot	P16035	Q6GXA8
Refseq	XM_001132362 (mRNA) XP_001132362 (protein)	NM_011594 (mRNA) NP_035724 (protein)
Location	Chr 17: 74.36 - 74.43 Mb	Chr 11: 118.12 - 118.17 Mb
Pubmed search	[1]	[2]

TIMP metallopeptidase inhibitor 2, a tissue inhibitor of metalloproteinases, also known as TIMP2, is a human gene, thought to be a metastasis suppressor.

This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.^[1]

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