TICAM2

From Wikipedia, the free encyclopedia

Toll-like receptor adaptor molecule 2

Identifiers

TICAM2; TRAM; MGC129876; MGC129877; TICAM-2; TIRAP3; TIRP

External IDs

OMIM: 608321 MGI: 3040056 HomoloGene: 11014

Gene ontology
Molecular Function:	• signal transducer activity • transmembrane receptor activity • protein binding
Cellular Component:	• membrane • integral to membrane
Biological Process:	• transport • positive regulation of I-kappaB kinase/NF-kappaB cascade

Orthologs

Human

Mouse

n/a

Refseq

NM_021649 (mRNA)
NP_067681 (protein)

NM_173394 (mRNA)
NP_775570 (protein)

Location

n/a

Chr 18: 46.68 - 46.7 Mb

Pubmed search

[1]

[2]

Toll-like receptor adaptor molecule 2, also known as TICAM2, is a human gene.^[1]

TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: TICAM2 toll-like receptor adaptor molecule 2.

[edit] Further reading

Sullivan C, Postlethwait JH, Lage CR, et al. (2007). "Evidence for evolving Toll-IL-1 receptor-containing adaptor molecule function in vertebrates.". J. Immunol. 178 (7): 4517–27. PMID 17372010.
Rowe DC, McGettrick AF, Latz E, et al. (2006). "The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.". Proc. Natl. Acad. Sci. U.S.A. 103 (16): 6299–304. doi:10.1073/pnas.0510041103. PMID 16603631.
Yamamoto M, Sato S, Hemmi H, et al. (2003). "TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway.". Nat. Immunol. 4 (11): 1144–50. doi:10.1038/ni986. PMID 14556004.
Oshiumi H, Sasai M, Shida K, et al. (2004). "TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta.". J. Biol. Chem. 278 (50): 49751–62. doi:10.1074/jbc.M305820200. PMID 14519765.
Fitzgerald KA, Rowe DC, Barnes BJ, et al. (2003). "LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.". J. Exp. Med. 198 (7): 1043–55. doi:10.1084/jem.20031023. PMID 14517278.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
Bin LH, Xu LG, Shu HB (2003). "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling.". J. Biol. Chem. 278 (27): 24526–32. doi:10.1074/jbc.M303451200. PMID 12721283.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703–13. PMID 10810093.