Thymosin beta-4, Y-chromosomal

From Wikipedia, the free encyclopedia

Thymosin, beta 4, Y-linked

Identifiers

TMSB4Y; MGC26307; TB4Y

External IDs

Gene ontology
Molecular Function:	• actin binding
Cellular Component:	• cytoplasm • cytoskeleton
Biological Process:	• cytoskeleton organization and biogenesis • regulation of actin polymerization and/or depolymerization • sequestering of actin monomers

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_004202 (mRNA)
NP_004193 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr Y: 14.32 - 14.33 Mb

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Pubmed search

[1]

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Thymosin, beta 4, Y-linked, also known as TMSB4Y, is a human gene.^[1]

This gene lies within the male specific region of chromosome Y. Its homolog on chromosome X escapes X inactivation and encodes an actin sequestering protein.^[1]

[edit] References

^ ^a ^b Entrez Gene: TMSB4Y thymosin, beta 4, Y-linked.

[edit] Further reading

Yu FX, Lin SC, Morrison-Bogorad M, et al. (1993). "Thymosin beta 10 and thymosin beta 4 are both actin monomer sequestering proteins.". J. Biol. Chem. 268 (1): 502–9. PMID 8416954.
Li X, Zimmerman A, Copeland NG, et al. (1997). "The mouse thymosin beta 4 gene: structure, promoter identification, and chromosome localization.". Genomics 32 (3): 388–94. doi:10.1006/geno.1996.0133. PMID 8838802.
Lahn BT, Page DC (1997). "Functional coherence of the human Y chromosome.". Science 278 (5338): 675–80. PMID 9381176.
"Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097–108. PMID 9847074.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.". Nature 423 (6942): 825–37. doi:10.1038/nature01722. PMID 12815422.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Torikai H, Akatsuka Y, Miyazaki M, et al. (2005). "A novel HLA-A*3303-restricted minor histocompatibility antigen encoded by an unconventional open reading frame of human TMSB4Y gene.". J. Immunol. 173 (11): 7046–54. PMID 15557202.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.